3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE

Product Name: 3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE
CAS No.: 115955-48-1
Chemical Name: 3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE
Synonyms: 3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE;2-Propen-1-one, 3-(dimethylamino)-1-(3-nitrophenyl)-;(2E)-3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
CBNumber: CB4729934
Molecular Formula: C11H12N2O3
Formula Weight: 220.22
MOL File: Mol file

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3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE Property

Melting point:: 109-111 °C
Boiling point:: 341.4±42.0 °C(Predicted)
Density: 1.202±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 6.24±0.70(Predicted)
Appearance: Light brown to brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2922390090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D495110
Product name: 3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
Packaging: 100mg
Price: $110
Updated: 2021/12/16

Matrix Scientific

Product number: 130871
Product name: 3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
Packaging: 1g
Price: $84
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD137190
Product name: (2E)-3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
Packaging: 250mg
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR110306
Product name: 3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
Packaging: 1g
Price: $108
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4956-1-25
Product name: 3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one
Packaging: 1g
Price: $128
Updated: 2021/12/16

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3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE Chemical Properties,Usage,Production

Synthesis

4637-24-5

121-89-1

115955-48-1

To a 250 mL round bottom flask was added 16.5 g (100 mmol) of m-nitroacetophenone, 26.5 mL of N,N-dimethylformamide dimethyl acetal (200 mmol) and 100 mL of xylene. The reaction mixture was heated to 140 °C and kept for 12 hours. After completion of the reaction, the mixture was cooled to room temperature and the precipitate was collected by filtration. The precipitate was washed sequentially with petroleum ether and ethyl ether, and then purified by silica gel column chromatography (eluent: ethyl acetate/cyclohexane, 25/75, v/v) to afford 19.6 g of the yellow solid product, 3-(dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one, in 89% yield. The structure of the product was determined by 1H NMR (200 MHz, DMSO-d6) δ 8.59 (t, 1H), 8.42-8.23 (m, 1H), 7.81 (d, J = 12.1 Hz, 1H), 7.70 (t, J = 7.9 Hz, 1H), 5.89 (d, J = 12.1 Hz, 1H), 3.17 (s, 1H), 2.95 (s , 1H) and confirmed by 13C NMR (50 MHz, DMSO-d6) δ 182.8, 155.2, 147.9, 141.6, 133.4, 129.8, 125.1, 121.5, 90.3, 44.7, 37.3.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1780 - 1783
[2] Patent: US2007/219183, 2007, A1. Location in patent: Page/Page column 11
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 10, p. 2735 - 2738
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 24, p. 6890 - 6892
[5] Patent: US2006/63784, 2006, A1. Location in patent: Page/Page column 43

3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE Suppliers

China 24 India 1 United Kingdom 3 United States 6 Global 34

Xinyanhe Pharmatech Co.,Ltd

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115955-48-1, 3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONERelated Search:

3-(DIMETHYLAMINO)-1-(3-NITROPHENYL)-2-PROPEN-1-ONE

(2E)-3-(Dimethylamino)-1-(3-nitrophenyl)prop-2-en-1-one

2-Propen-1-one, 3-(dimethylamino)-1-(3-nitrophenyl)-

115955-48-1