ChemicalBook > CAS DataBase List > 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE

7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE

Product Name: 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
CAS No.: 204452-91-5
Chemical Name: 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
Synonyms: EOS-61216;7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]PHTHYRIDINE;7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE;1,8-Naphthyridine, 7-(dimethoxymethyl)-1,2,3,4-tetrahydro-
CBNumber: CB4731401
Molecular Formula: C11H16N2O2
Formula Weight: 208.26
MOL File: 204452-91-5.mol

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7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Property

Melting point:: 95°C
Boiling point:: 362.5±42.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 10.72±0.40(Predicted)
Appearance: Off-white to yellow Solid
InChIKey: KKTPPUNNCIHOFA-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000835
Product name: 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
Purity: Aldrich
Packaging: 1g
Price: $216
Updated: 2025/07/31

TRC

Product number: D496193
Product name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
Packaging: 500mg
Price: $265
Updated: 2021/12/16

TRC

Product number: D496193
Product name: 7-(Dimethoxymethyl)-1,2,3,4-tetrahydro-1,8-naphthyridine
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Matrix Scientific

Product number: 018159
Product name: 7-Dimethoxymethyl-1,2,3,4-tetrahydro-[1,8]naphthyridine
Packaging: 500mg
Price: $123
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0028008
Product name: 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE
Purity: 95.00%
Packaging: 500MG
Price: $712.64
Updated: 2021/12/16

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7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Chemical Properties,Usage,Production

Synthesis

204452-90-4

204452-91-5

General procedure for the synthesis of 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine from [1,8]naphthyridine-2-carboxaldehyde dimethanol: A solution of [1,8]naphthyridine-2-carboxaldehyde dimethanol (20.0 g, 97.9 mmol) in ethanol (400 mL) was hydrogenated catalytically by PtO2 (778 mg) in a hydrogen atmosphere at room temperature and at 1 atmosphere pressure for 18 hours. Upon completion of the reaction, the reaction mixture was filtered through Solka Floc and washed with ethanol-water (1:2, v/v) mixture. The filtrate and washings were combined and concentrated under reduced pressure to remove ethanol. During concentration, the product gradually crystallized. The crystals were collected by filtration and dried under reduced pressure to afford 7-dimethoxymethyl-1,2,3,4-tetrahydro[1,8]naphthyridine (18.7 g, 92% yield) with a melting point of 91-92.5 °C.1H NMR (300 MHz, CDCl3): δ 7.08 (d, J = 7.4 Hz, 1H), 6.62 (d, J = 7.4 Hz, 1H), 5.07 ( s, 2H; 1H exchangeable with D2O), 3.37-3.29 (m, 2H), 3.29 (s, 6H), 2.64 (t, J = 6.3 Hz, 2H), 1.86-1.78 (m, 2H).13C NMR (75.5 MHz, CDCl3): δ 155.9, 153.0, 136.3, 116.0, 109.8 , 103.9, 53.3, 41.5, 26.6, 21.2.

References

[1] The Journal of organic chemistry, 2004, vol. 69, # 6, p. 1959 - 1966
[2] Patent: WO2016/154369, 2016, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/269225, 2008, A1. Location in patent: Page/Page column 37-38
[4] Patent: US2003/229079, 2003, A1. Location in patent: Page 36
[5] Patent: WO2007/79214, 2007, A2. Location in patent: Page/Page column 102

7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE manufacturers

Career Henan Chemical Co

Product: 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE 204452-91-5
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

204452-91-5, 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINERelated Search:

1,2,3,4-TETRAHYDRO-1,8-NAPHTHYRIDINE (6-aminopyridin-2-yl)methanol 7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE CHEMBRDG-BB 4011741 1,8-Naphthyridine,1,2,3,4-tetrahydro-7-methyl-(9CI)

7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]NAPHTHYRIDINE

7-DIMETHOXYMETHYL-1,2,3,4-TETRAHYDRO-[1,8]PHTHYRIDINE

EOS-61216

1,8-Naphthyridine, 7-(dimethoxymethyl)-1,2,3,4-tetrahydro-

204452-91-5

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