13,14-DIHYDRO PROSTAGLANDIN E1-D4
- Product Name
- 13,14-DIHYDRO PROSTAGLANDIN E1-D4
- Chemical Name
- 13,14-DIHYDRO PROSTAGLANDIN E1-D4
- Synonyms
- PGE0-D4;13,14-DIHYDRO PROSTAGLANDIN E1-D4;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTAN-1-OIC-3,3,4,4-D4 ACID
- CBNumber
- CB4736552
- Molecular Formula
- C20H32D4O5
- Formula Weight
- 360.52
- MOL File
- Mol file
13,14-DIHYDRO PROSTAGLANDIN E1-D4 Property
- solubility
- DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 50 mg/mlPBS (pH 7.2): 1 mg/ml
N-Bromosuccinimide Price
- Product number
- 9000281
- Product name
- 13,14-dihydro Prostaglandin E1-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 25μg
- Price
- $105
- Updated
- 2024/03/01
- Product number
- 9000281
- Product name
- 13,14-dihydro Prostaglandin E1-d4
- Purity
- ≥99% deuterated forms (d1-d4)
- Packaging
- 50μg
- Price
- $195
- Updated
- 2024/03/01
13,14-DIHYDRO PROSTAGLANDIN E1-D4 Chemical Properties,Usage,Production
Description
13,14-dihydro Prostaglandin E1-d4 (13,14-dh PGE1-d4) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 13,14-dh PGE1 by GC- or LC-mass spectrometry. 13,14-dh PGE1 is an inhibitor of ADP-induced platelet aggregation in human platelet-rich plasma and washed platelets with IC50 values of 31 and 21 nM, respectively.1 13,14-dh PGE1 is a slightly more potent inhibitor of ADP-induced human platelet aggregation than PGE1 which has an IC50 of 40 nM.2 Also, 13,14-dh PGE1 activates adenylate cyclase in NCB-20 hybrid cells with a Kact of 668 nM.3WARNING This product is not for human or veterinary use.
References
[1] G. KOBZAR. Comparison of the inhibitory effect of E-prostaglandins in human and rabbit platelet-rich plasma and washed platelets[J]. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology, 1993, 106 2: Pages 489-494. DOI: 10.1016/0742-8413(93)90168-k
[2] I. JÄRVING. ANTIAGGREGATING POTENCY OF E-TYPE PROSTAGLANDINS IN HUMAN AND RABBIT PLATELETS[J]. Proceedings of the Estonian Academy of Sciences. Chemistry, 1991, 32 1. DOI: 10.3176/chem.1991.3.09
[3] I.A. BLAIR J. M C N HENSBY. PROSTACYCLIN-DEPENDENT ACTIVATION OF ADENYLATE CYCLASE IN A NEURONAL SOMATIC CELL HYBRID: PROSTANOID STRUCTURE-ACTIVITY RELATIONSHIPS[J]. British Journal of Pharmacology, 1980, 69 3: 519-525. DOI: 10.1111/j.1476-5381.1980.tb07043.x
13,14-DIHYDRO PROSTAGLANDIN E1-D4 Preparation Products And Raw materials
Raw materials
Preparation Products
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