N-Boc-2-amino-5-bromothiazole

Product Name: N-Boc-2-amino-5-bromothiazole
CAS No.: 405939-39-1
Chemical Name: N-Boc-2-amino-5-bromothiazole
Synonyms: 2-(Boc-aMino)-5-broMothiazole;TERT-BUTYL 5-BROMOTHIAZOL-2-YLCARBAMATE;CAS:405939-39-1;N-BOC-2-AMINO-5-BROMOTHIAZOLE;N-Boc-2-Amino-5-bromothiazole95%;tert-butyl N-(5-bromothiazol-2-yl)carbamate;TERT-BUTYL (5-BROMO-1,3-THIAZOL-2-YL)CARBAMATE;tert-butyl N-(5-broMo-1,3-thiazol-2-yl)carbaMate;(5-BroMo-thiazol-2-yl)-carbaMic acid tert-butyl ester;2-amino-5-bromo-2H-thiazole-3-carboxylic acid tert-butyl ester
CBNumber: CB4738697
Molecular Formula: C8H11BrN2O2S
Formula Weight: 279.15
MOL File: 405939-39-1.mol

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N-Boc-2-amino-5-bromothiazole Property

Melting point:: 149 °C
Density: 1.574±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.58±0.70(Predicted)
form: Solid
Appearance: Off-white to yellow Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C8H11BrN2O2S/c1-8(2,3)13-7(12)11-6-10-4-5(9)14-6/h4H,1-3H3,(H,10,11,12)
InChIKey: OIBKBVFFZYCBAQ-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=NC=C(Br)S1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B603143
Product name: N-Boc-2-amino-5-bromothiazole
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139344
Product name: tert-Butyl (5-bromothiazol-2-yl)carbamate
Packaging: 2g
Price: $56
Updated: 2021/12/16

AK Scientific

Product number: W6110
Product name: N-Boc-2-amino-5-bromothiazole
Packaging: 1g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H70-9-30
Product name: N-Boc-2-amino-5-bromothiazole
Purity: 95.0%
Packaging: 1g
Price: $72
Updated: 2021/12/16

ChemScene

Product number: CS-W007907
Product name: tert-Butyl(5-bromothiazol-2-yl)carbamate
Purity: 99.64%
Packaging: 5g
Price: $49
Updated: 2021/12/16

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N-Boc-2-amino-5-bromothiazole Chemical Properties,Usage,Production

Uses

N-Boc-2-amino-5-bromothiazole is used as pharmaceutical intermediate.

Synthesis

24424-99-5

61296-22-8

405939-39-1

General procedure for the synthesis of N-BOC-2-amino-5-bromothiazole from di-tert-butyl dicarbonate and 2-amino-5-bromothiazole hydrobromide: di-tert-butyl dicarbonate [(Boc)2O, 100.7 g, 0.461 mol, 1.2 eq.] was added to 900 mL of THF and 135 mL of pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) containing 2-amino-5-bromothiazole monohydrobromide (100 g, 0.385 mol, 1.0 eq.) and 4-(dimethylamino)pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq.) in a mixture of 900 mL THF and 135 mL Et3N. The reaction mixture was cooled to 0 °C using an ice bath. Subsequently, the reaction mixture was stirred at room temperature overnight, followed by vacuum concentration. The residue was stirred in EtOAc/heptane (1:10, 250 mL) at room temperature overnight and then filtered. The filtrate was washed with brine, dried, filtered, and concentrated in vacuo to afford the intermediate N-BOC-2-amino-5-bromothiazole as a yellow solid (91% yield).

References

[1] Synthesis, 2010, # 7, p. 1091 - 1096
[2] Patent: WO2018/112136, 2018, A1. Location in patent: Paragraph 00261
[3] Patent: US2009/36467, 2009, A1. Location in patent: Page/Page column 64; 72; 73
[4] Patent: US2012/108591, 2012, A1. Location in patent: Page/Page column 29
[5] Patent: WO2015/25172, 2015, A1. Location in patent: Page/Page column 118; 119

N-Boc-2-amino-5-bromothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Boc-2-amino-5-bromothiazole Suppliers

China 159 Germany 2 India 4 United Kingdom 3 United States 18 Global 186

Entrenture (Lanzhou) Biomedical Technology Co., Ltd

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View Lastest Price from N-Boc-2-amino-5-bromothiazole manufacturers

Henan Fengda Chemical Co., Ltd

Product: N-BOC-2-AMINO-5-BROMOTHIAZOLE 405939-39-1
Price: US $5.00-0.20/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-02

Career Henan Chemical Co

Product: N-BOC-2-AMINO-5-BROMOTHIAZOLE 405939-39-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 659
Release date: 2019-09-01

405939-39-1, N-Boc-2-amino-5-bromothiazoleRelated Search:

N-BOC-2-AMINO-5-BROMOTHIAZOLE-4-CARBOXYLIC ACID 5-Bromothiazole 2-Amino-5-bromothiazole 2-Amino-5-bromobenzothiazole 5-BROMO-2-TERT-BUTOXYCARBONYLAMINOTHIAZOLE-4-CARBOXYLIC ACID METHYL ESTER N,N-DI-BOC-2-AMINO-5-BROMOTHIAZOLE (5-BROMO-THIAZOL-2-YL)-PHENYL-CARBAMIC ACID TERT-BUTYL ESTER N-BOC-2-AMINO-5-BROMOTHIAZOLE Carbamic acid, N-(5-bromo-4-cyano-2-thiazolyl)-, 1,1-dimethylethyl ester

TERT-BUTYL (5-BROMO-1,3-THIAZOL-2-YL)CARBAMATE

TERT-BUTYL 5-BROMOTHIAZOL-2-YLCARBAMATE

N-BOC-2-AMINO-5-BROMOTHIAZOLE

N-Boc-2-Amino-5-bromothiazole95%

tert-butyl N-(5-broMo-1,3-thiazol-2-yl)carbaMate

(5-BroMo-thiazol-2-yl)-carbaMic acid tert-butyl ester

2-(Boc-aMino)-5-broMothiazole

2-amino-5-bromo-2H-thiazole-3-carboxylic acid tert-butyl ester

tert-butyl N-(5-bromothiazol-2-yl)carbamate

Carbamic acid, N-(5-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester

CAS:405939-39-1

405939-39-1

C8H11BrN2O2S

Thiazole

API intermediates