Hordenine
- Product Name
- Hordenine
- CAS No.
- 539-15-1
- Chemical Name
- Hordenine
- Synonyms
- Hordenin;Hordeine;Anhalin;Cactine;Anhaline;Hordetin;Ordenina;Ordenine;Eremursin;Hordenine
- CBNumber
- CB4747471
- Molecular Formula
- C10H15NO
- Formula Weight
- 165.23
- MOL File
- 539-15-1.mol
Hordenine Property
- Melting point:
- 117-118°
- Boiling point:
- bp11 173°
- Density
- 1.0203 (rough estimate)
- refractive index
- 1.4820 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 10.05±0.26(Predicted)
- form
- Solid
- color
- Pale Yellow to Dark Beige
- Merck
- 14,4746
- BRN
- 2207615
- LogP
- 1.400 (est)
- CAS DataBase Reference
- 539-15-1(CAS DataBase Reference)
- NIST Chemistry Reference
- Phenol, 4-[2-(dimethylamino)ethyl]-(539-15-1)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 04476
- Product name
- Hordenine
- Purity
- ≥97.0% (HPLC)
- Packaging
- 100mg
- Price
- $96.2
- Updated
- 2024/03/01
- Product number
- PHL80469
- Product name
- Hordenine
- Purity
- phyproof? Reference Substance
- Packaging
- 50mg
- Price
- $382
- Updated
- 2024/03/01
- Product number
- 04476
- Product name
- Hordenine
- Purity
- ≥97.0% (HPLC)
- Packaging
- 1g
- Price
- $713
- Updated
- 2024/03/01
- Product number
- H1351
- Product name
- Hordenine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $38
- Updated
- 2024/03/01
- Product number
- H1351
- Product name
- Hordenine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $115
- Updated
- 2024/03/01
Hordenine Chemical Properties,Usage,Production
Description
Hordenine (Item No. 21626) is a naturally occurring alkaloid found in a variety of plants, most commonly germinated barley (Hordeum species) from which the name is derived, and is structurally classified as a phenethylamine. It is biosynthesized by the step-wise double methylation of tyramine . Hordenine binds to and activates the dopamine D2 receptor (Ki = 13 μM) but antagonizes D2 receptor β-arrestin recruitment. It inhibits tyrosinase activity and expression at concentrations ≥ 50 μM resulting in reduced melanin accumulation in human melanocytes. Hordenine is present in significant amounts in beer and can be measured in serum in the free form, for up to 2 hours, and the glucuronidated form, for up to 6 hours, after beer consumption. This product is intended for research and forensic applications.
Chemical Properties
Light yellow solid
Uses
Hordenine is suitable to study the effect of reed canary grass alkoloids on in vito digestibility. It is also suitable for use as a standard to identify endogenous hordenine in ungerminated and germinated barley by HPLC/diode array detection analysis. Hordenine may be used as an analytical reference material and in research on the activities of phenethylamine type alkaloids.
Uses
A phenethylamine alkaloid with antibacterial and antibiotic properties found mainly in plants from the cactaceae family. It showed effects similar to Cytosine (C998950) and acted as a depressant on the central nervous system (CNS) during animal testing.
Definition
ChEBI: Hordenine is a phenethylamine alkaloid. It has a role as a human metabolite and a mouse metabolite.
Biochem/physiol Actions
Hordenine is an alkaloid found in plants, e.g. the roots of germinating barley and marine algae. It is a metabolite in tyrosine metabolism, biosynthesized from tyramine by two subsequent N-methylations, it is metabolized by monoamine oxidase. Hordenine is a sympathomimetic and its pharmacological actions are of interest, as it is occasionally found in post race urine samples. Hordenine inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production. cAMP is involved in the expression of melanogenesis-related proteins. Hordenine may be used in the inhibition of hyperpigmentation. It is present in barley roots from the first day of seed germination, but is not present in seeds.
Purification Methods
Crystallise Hordenine from EtOH or H2O and sublime it at 105o/5mm. The 4,4’-dichlorodiphenyl disulfimide salt has m 145-146o (from Me2CO/H2O) [Runge et al. Chem Ber 88 50 1955]. [Beilstein 13 H 626, 13 I 236, 13 II 356, 13 III 1640, 13 IV 1790.]
Hordenine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Hordenine manufacturers
- Product
- Hordenine 539-15-1
- Price
- US $200.00-85.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-23
- Product
- Hordenine 539-15-1
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 4-(2-dimethylaminoethyl)phenol 539-15-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99.0%
- Supply Ability
- 20tons
- Release date
- 2023-09-06