AC187

ChemicalBook > CAS DataBase List > AC187

Product Name: AC187
CAS No.: 151804-77-2
Chemical Name: AC187
Synonyms: AC187;ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT;AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn??,Tyr??)-Calcitonin (8-32) (salmon I);ACETYL-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I);Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I) AC187;8-32-Calcitonin (salmon reduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-;AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2;ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2;Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt
CBNumber: CB4752202
Molecular Formula: C127H205N37O40
Formula Weight: 2890.26
MOL File: 151804-77-2.mol

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AC187 Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble to 1 mg/ml in H2O
form: powder
color: white to off-white
Water Solubility: Soluble to 1 mg/ml in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1418
Product name: Acetyl-[Asn30, Tyr32]-Calcitonin Fragment 8-32 trifluoroacetate salt
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $391
Updated: 2024/03/01

Tocris

Product number: 3419
Product name: AC187
Packaging: 500U
Price: $338
Updated: 2021/12/16

Usbiological

Product number: 254508
Product name: AC 187
Packaging: 500ug
Price: $616
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA109403
Product name: Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt
Packaging: 1mg
Price: $920
Updated: 2021/12/16

ApexBio Technology

Product number: B5424
Product name: AC187
Packaging: 500ug
Price: $497
Updated: 2021/12/16

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AC187 Chemical Properties,Usage,Production

Biological Activity

amylin is a 37-amino acid peptide co-secreted with insulin from pancreatic β-ells. the plasma concentration of amyline increases with nutrient stimuli. ac187 is a potent amylin antagonist

in vitro

ac187 potently competes for rat amylin binding at high affinity sites such as rat nucleus accumbens membranes which have been useful in developing a number of selective ligands, including ac187. the kd for amylin at this site is 28 pm, and the ki for ac187 is 79 pm. ac187 is relatively selective in competing for amylin binding, displacing amylin from nucleus accumbens membranes with over 400-fold greater potency [1].

in vivo

ac187 was able to inhibit metabolic responses to exogenous amylin in the intact animal. an infusion of ac187 that was itself without effect on lactate levels in anesthetized rats, inhibited by more than 90% the lactate increment evoked by infusions of rat amylin. other experiments have shown that ac187-induced amylin blockade action is surmountable by higher doses of amylin, indicative of a competitive antagonism [1].

storage

Store at -20°C

References

[1] young aa, gedulin b, gaeta ls, prickett ks, beaumont k, larson e, rink tj. selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. evidence for a metabolic role of endogenous amylin. febs lett. 1994 may 2;343(3):237-41.

AC187 Preparation Products And Raw materials

Raw materials

Preparation Products

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151804-77-2, AC187Related Search:

Calcitonin AC187

ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT

AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2

Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I) AC187

ACETYL-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I)

ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2

AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I)

AC187

Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I) trifluoroacetate salt Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt

8-32-Calcitonin (salmon reduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-

Acetyl-(Asn??,Tyr??)-Calcitonin (8-32) (salmon I)

151804-77-2

C127H205N37O40