PICROSIDE I

Product Name: PICROSIDE I
CAS No.: 27409-30-9
Chemical Name: PICROSIDE I
Synonyms: PicrosideⅠ;PICROSIDE I;Picroside-Ⅰ;Amphicoside Ⅰ;AMphicoside I;Amphicoside Ⅰ;Amphicoside Ⅰ3;Picroside I-RM;Picroside I(AS);PICOLINIC ACID(P)
CBNumber: CB4755915
Molecular Formula: C24H28O11
Formula Weight: 492.47
MOL File: 27409-30-9.mol

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PICROSIDE I Property

Boiling point:: 778.6±60.0 °C(Predicted)
Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: ethanol: soluble1mg/mL, clear, colorless
form: powder
pka: 12.70±0.70(Predicted)
color: White
InChIKey: BSYHSWKTXMTFNF-NTLZGZQOSA-N
SMILES: [C@]12(CO)O[C@H]1[C@H]([C@]1([H])C=CO[C@@H](O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@]21[H])OC(=O)/C=C/C1=CC=CC=C1 |&1:0,4,5,6,11,13,14,16,17,19,24,r|

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G9923
Product name: Picroside I
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $339.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1538312
Product name: Picroside I
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 20mg
Price: $866
Updated: 2025/07/31

TCI Chemical

Product number: P2593
Product name: Picroside I
Packaging: 10MG
Price: $132
Updated: 2025/07/31

TCI Chemical

Product number: P2593
Product name: Picroside I
Packaging: 50MG
Price: $460
Updated: 2025/07/31

Cayman Chemical

Product number: 15431
Product name: Picroside I
Purity: ≥98%
Packaging: 5mg
Price: $72
Updated: 2024/03/01

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PICROSIDE I Chemical Properties,Usage,Production

Description

Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas. Picroside I is an iridoid glycoside found in picroliv. By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver. Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 μM. At concentrations as low as 5 μM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein.

Chemical Properties

Yellow needle-shaped crystals, soluble in methanol, derived from Picrorhizoma Coptidis.

Uses

Picroside I acts as an oxygen free radical scavenger and thus promotes anti-inflammatory activity and may be used in the treatment of arthritis.

in vivo

Picroside I (20 mg/kg, o.p, 12 d) reduces AHR in the experimental asthma model and reduces OVA-associated IgE levels^[2].

Animal Model:	Ovalbumin (OVA) systematic sensitization BALB/c mice model^[2]
Dosage:	0.2, 2.0 and 20 mg/kg
Administration:	Orally, once daily, from day 20 to day 32
Result:	Inhibited allergen-triggered inflammatory cell infiltration.

IC 50

STAT6

References

[1] C. GIRISH Suresh C P. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin[J]. Fundamental & Clinical Pharmacology, 2008, 22 6: 623-632. DOI: 10.1111/j.1472-8206.2008.00618.x
[2] YOGESH DWIVEDI. Picroliv and its Components Kutkoside and Picroside I Protect Liver Against Galactosamine-Induced Damage in Rats[J]. Basic & Clinical Pharmacology & Toxicology, 1992, 71 5: 383-387. DOI: 10.1111/j.1600-0773.1992.tb00566.x
[3] PING LI . Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells[J]. European journal of pharmacology, 2000, 406 2: Pages 203-208. DOI: 10.1016/s0014-2999(00)00662-2
[4] PING LI. Picrosides I and II, selective enhancers of the mitogen-activated protein kinase-dependent signaling pathway in the action of neuritogenic substances on PC12D cells[J]. Life sciences, 2002, 71 15: Pages 1821-1835. DOI: 10.1016/s0024-3205(02)01949-5
[5] I A NAJAR. Modulation of P-glycoprotein ATPase activity by some phytoconstituents.[J]. Phytotherapy Research, 2010: 454-458. DOI: 10.1002/ptr.2951

PICROSIDE I Preparation Products And Raw materials

Raw materials

Preparation Products

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PICROSIDE I Suppliers

China 228 Germany 2 India 3 Japan 1 United Kingdom 4 United States 20 Global 258

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

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View Lastest Price from PICROSIDE I manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Picroside I 27409-30-9
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-10

Career Henan Chemical Co

Product: PICROSIDE I 27409-30-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-18

27409-30-9, PICROSIDE IRelated Search:

Picroside-2,PICROSIDE ò ,PICROSIDE II TRANS-2-METHYLCYCLOPENTANOL ISO-AMYL-CROTONATE 2-Methyl-2,3-epoxy-1-propanol BUTYL CROTONATE HEPTYL-BETA-D-GLUCOPYRANOSIDE PICROSIDE I 2-Methoxyethyl acrylate Isobutyl cinnamate (TETRAHYDRO-PYRAN-3-YL)-METHANOL 3-METHYLTETRAHYDROPYRAN FEMA 3354 TRANS-2,3-EPOXYBUTANE (R)-(-)-PENTEN-2-OL 4-Hydroxybutyl acrylate HEXANAL DIMETHYL ACETAL Cyclopentene oxide 1,3-cyclopentanediol

PICROSIDE I

beta-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-

Picroside-Ⅰ

6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl,6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]-

β-D-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-

[1aS-[1aalpha,1bbeta,2beta(E),5abeta,6beta,6aalpha]]-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-(3-phenyl-2-propenoate) beta-D-glucopyranoside

β-d-Glucopyranoside, 1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-(3-phenyl-2-propenoate), [1aS-[1aα,1bβ,2β(E),5aβ,6β,6aα]]-

PICOLINIC ACID(P)

Amphicoside Ⅰ

Other Cas No, 76248-14-1

(1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-Hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-β-D-glucopyranoside 6-[(2E)-3-phenyl-2-propenoate]

AMphicoside I

Picroside I, 98%, from Picrorhiza scrophulariiflora Pennel

β-D-Glucopyranoside, (1aS,1bS,2S,5aR,6S,6aS)-1a,1b,2,5a,6,6a-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl, 6-[(2E)-3-phenyl-2-propenoate]

(1aS,1bS,2S,5aR,6S,6aS)-6-Hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[4,5]cyclopenta[1,2-c]pyran-2-yl 6-O-[(2E)-3-phenyl-2-propenoyl]-beta-D-glucopyranoside

[(2R,3S,4S,5R,6S)-6-[[(1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-2,5a,6,6a-tetrahydro-1bH-oxireno[5,6]cyclopenta[1,3-c]pyran-2-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methyl (E)-3-phenylprop-2-enoate

Amphicoside Ⅰ3

((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((1aS,1bS,2S,5aR,6S,6aS)-6-hydroxy-1a-(hydroxymethyl)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl cinnamate

Picroside I (20 mg)

Picroside I(AS)

Picroside I-RM

Amphicoside Ⅰ

PicrosideⅠ

27409-30-9

Inhibitors

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract