1,3-Diethyl-1,3-diphenylurea Property

Melting point:

73-75 °C(lit.)

Boiling point:

411.52°C (rough estimate)

Density 

1.0208 (rough estimate)

vapor density 

9.3 (vs air)

vapor pressure 

0Pa at 25℃

refractive index 

1.5486 (estimate)

Flash point:

150℃

storage temp. 

Sealed in dry,Room Temperature

solubility 

acetone: soluble(lit.)

pka

0.63±0.50(Predicted)

form 

Solid

color 

White to Grey

Water Solubility 

40.5mg/L at 20℃

Merck 

13,3144

Stability:

Shock sensitive.

LogP

3.98 at 23℃

CAS DataBase Reference

85-98-3(CAS DataBase Reference)

EPA Substance Registry System

N,N'-Diethylcarbanilide (85-98-3)

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36-52/53-22

Safety Statements 

22-24/25-36/37-16-61

WGK Germany 

2

RTECS 

FE0350000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

1,3-Diethyl-1,3-diphenylurea Chemical Properties,Usage,Production

Description

Ethylcentralite (EC), also known as 1,3-Diethyl-1,3-diphenylurea, is a unique compound derived from ethylenediamine, with extensive research focused on its applications in laboratory experiments. The investigation of EC encompasses its potential as an anti-inflammatory, antioxidant, and cognitive enhancer. Additionally, EC shows progression in cancer and neurodegenerative disease research and gene therapy. Furthermore, EC may act as a chelator, effectively binding to metals like iron and copper to prevent their accumulation in the body.

Chemical Properties

white crystalline powder

Uses

1,3-Diethyl-1,3-diphenylurea is a gunshot residue and a stabilizer for smokeless powder.

Uses

As stabilizer of smokeless explosives.

General Description

White flakes or white crystalline solid. Peppery odor.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

N,N'-DIETHYL-N,N'-DIPHENYLUREA (1,3-Diethyl-1,3-diphenylurea) is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). N,N'-DIETHYL-N,N'-DIPHENYLUREA is incompatible with acids and oxidizing agents. N,N'-DIETHYL-N,N'-DIPHENYLUREA reacts violently when severely shocked or exposed to extreme temperatures.

Health Hazard

ACUTE/CHRONIC HAZARDS: N,N'-DIETHYL-N,N'-DIPHENYLUREA may react violently when severely shocked or heated to extreme temperatures.

Fire Hazard

N,N'-DIETHYL-N,N'-DIPHENYLUREA is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. Combustible when exposed to heat or flame. Probably a slight explosion hazard, although it is a component of smokeless explosive mixtures. When heated o decomposition it burns and emits very toxic fumes of NOx. To fight fire, use dry chemical, CO2, spray or mist. An explosion regulator.

Synthesis

The specific synthesis steps of 1,3-Diethyl-1,3-diphenylurea are as follows: A 10 mL Schlenk tube equipped with a magnetic stirring bar was charged with aryl carbamoyl chlorides and KHCO3, and then Pd(PPh3)4 were added. Finally, 1,4-dioxane was added to the mixture via syringe at room temperature under N2. The tube was sealed and put into a preheated oil bath a 100 °C for 48 h. The mixture was cooled to room temperature, quenched with water, and diluted with ethyl acetate. The layers were separated, and the aqueous layer was extracted with 2 × 5 mL of ethyl acetate. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The crude product was then purified by flash chromatography on silica gel (H), eluting with 30-35% ethyl acetate/petroleum ether.