Cbz-N-methyl-L-valine

Product Name: Cbz-N-methyl-L-valine
CAS No.: 42417-65-2
Chemical Name: Cbz-N-methyl-L-valine
Synonyms: Z-MEVAL-OH;Z-L-MEVAL-OH;Cbz-N-Me-Val;Z-N-ME-VALINE;Z-N-ME-VAL-OH;Z-N-Me-L-Val-OH;CBZ-N-ME-VAL-OH;Cbz-N-Me-L-Val-OH;Z-METHYL-L-VALINE;Cbz-N-D-Me-Val-OH
CBNumber: CB4764597
Molecular Formula: C14H19NO4
Formula Weight: 265.3
MOL File: 42417-65-2.mol

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Cbz-N-methyl-L-valine Property

Melting point:: 68-70 °C(lit.)
Boiling point:: 407.1±34.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka: 4.01±0.10(Predicted)
form: Crystalline Solid
color: White
Major Application: peptide synthesis
InChI: 1S/C14H19NO4/c1-10(2)12(13(16)17)15(3)14(18)19-9-11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3,(H,16,17)/t12-/m0/s1
InChIKey: NNEHOKZDWLJKHP-LBPRGKRZSA-N
SMILES: CC(C)[C@H](N(C)C(=O)OCc1ccccc1)C(O)=O
CAS DataBase Reference: 42417-65-2(CAS DataBase Reference)

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Safety

Safety Statements: 36/37
WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 00913
Product name: Z-N-Me-Val-OH
Purity: ≥98.0%
Packaging: 500MG
Price: $158
Updated: 2023/01/07

TRC

Product number: B286630
Product name: (S)-N-(Benzyloxycarbonyl)-N-methylvaline
Packaging: 5g
Price: $225
Updated: 2021/12/16

Usbiological

Product number: 283786
Product name: Z-N-methyl-L-valine
Packaging: 1g
Price: $360
Updated: 2021/12/16

Chem-Impex

Product number: 02680
Product name: Z--methyl-L-valine
Purity: ≥ 98% (HPLC)
Packaging: 1G
Price: $41.4
Updated: 2021/12/16

Activate Scientific

Product number: AS88162
Product name: Cbz-N-methyl-L-valine
Purity: 95% ee
Packaging: 1g
Price: $70
Updated: 2021/12/16

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Cbz-N-methyl-L-valine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

(S)-N-(Benzyloxycarbonyl)-N-methylvaline has been used as a reactant in the synthesis of a biologically active cyclodepsipeptide destruxin E which is a potent negative regulator of osteoclast morphology.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

Under argon atmosphere, 60% sodium hydroxide (5 g, 0.125 mol) was added in one portion to a stirred mixture of Cbz-L-valine (9.5 g, 0.038) in anhydrous THF (150 mL) at 0??C and stirred simultaneously for 30 minutes. mol) in anhydrous THF (150 mL) and stir for 30 minutes. Iodomethane (20 mL, 0.32 mol) was added and the resulting mixture was stirred overnight at room temperature. Ice water (200mL) was poured into the mixture at 0??C and the resulting mixture was extracted with ether (2x200mL). The aqueous layer was acidified to pH using dilute HCl solution 1.5 and extracted with ethyl acetate (3x200mL). The combined organic extracts were washed with saturated sodium thiosulfate solution (100 mL), dried (Na2SO4) and evaporated in vacuo to give N and evaporated in vacuum to give N-Cbz-N-methyl-L-valine (5 g, 55%) as a colorless viscous oil which can be used in the next step without purification.

Cbz-N-methyl-L-valine Preparation Products And Raw materials

Raw materials

Preparation Products

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Cbz-N-methyl-L-valine Suppliers

China 132 Germany 4 India 4 Japan 3 Switzerland 2 United Kingdom 3 United States 13 Global 161

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View Lastest Price from Cbz-N-methyl-L-valine manufacturers

Sichuan Jiaying Lai Technology Co.,LTD

Product: Cbz-N-Me-Val-OH 42417-65-2
Price: US $1.00/g
Min. Order: 10g
Purity: 98%
Supply Ability: 100kg
Release date: 2019-07-14

Career Henan Chemical Co

Product: Cbz-N-methyl-L-valine 42417-65-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2019-08-31

42417-65-2, Cbz-N-methyl-L-valineRelated Search:

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BENZYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE

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(S)-2-((benzyloxycarbonyl)(methyl)amino)-3-methylbutanoic acid

(2S)-2-[[(benzyloxy)carbonyl](Methyl)aMino]-3-Methylbutanoic acid

(S)-N-(Benzyloxycarbonyl)-N-Methylvaline

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Cbz-N-Me-L-Val-OH

Z-<I>N</I>-Me-Val-OH

Z-N-Me-L-Val-OH

Z-N-methyl-L-valine≥ 98% (HPLC)

Z-L-MEVAL-OH

Z-MEVAL-OH

Z-METHYL-L-VALINE

Z-N-METHYL-L-VALINE

Z-N-ME-VALINE

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N-BENZYLOXYCARBONYL-N-METHYL-L-VALINE

N-ALPHA-CBZ-N-ALPHA-METHYL-L-VALINE

N-ALPHA-CARBOBENZOXY-N-ALPHA-METHYL-L-VALINE

N-ALPHA-BENZYLOXYCARBONYL-N-ALPHA-METHYL-L-VALINE

Cbz-N-D-Me-Val-OH

Z-N-ME-VAL 98.5+%

CBZ-N-ME-VAL-OH

NALPHA-Benzyloxycarbonyl-N-methyl-L-valine

Cbz-N-methyl-L-valine

N-(Benzyloxycarbonyl)-N-methylvaline

L-Valine, N-methyl-N-[(phenylmethoxy)carbonyl]-

(2S)-3-methyl-2-[methyl(phenylmethoxycarbonyl)amino]butanoic acid

(2S)-3-methyl-2-[methyl(phenylmethoxycarbonyl)amino]butanoicaci

Cbz-N-methyl-L-valine USP/EP/BP

Ganciclovir EP Impurity 10

Cbz-N-Me-Val

Z-N-α-Methyl-L-valine

CBZ- N-methyl valine

42417-65-2

N-Methyl Amino Acids

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acid Derivatives