Tacrolimus Monohydrate

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Tacrolimus Monohydrate

Product Name: Tacrolimus Monohydrate
CAS No.: 109581-93-3
Chemical Name: Tacrolimus Monohydrate
Synonyms: Tacrolimus monohydrate;FK-506;135175;CS-1308;Tacarolimus;[3R[E(1S,3S,4S);tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);FR900506 monohydrate
CBNumber: CB4772400
Molecular Formula: C44H71NO13
Formula Weight: 822.05
MOL File: 109581-93-3.mol

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Tacrolimus Monohydrate Property

Melting point:: 127-129°
alpha: D23 -84.4° (c = 1.02 in chloroform)
storage temp.: -20°C
solubility: DMSO: soluble20mg/mL
form: powder
color: White to Almost white
Merck: 14,9025
InChI: InChI=1/C44H69NO12.H2O/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7;/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3;1H2/b25-19-,27-21+;/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+;/s3
InChIKey: NWJQLQGQZSIBAF-MLAUYUEBSA-N
SMILES: O([C@H]1C[C@@H](C)[C@@]2(C(C(N3CCCC[C@@]3([H])C(O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)C=C(C)C[C@H](C)C[C@H](OC)[C@@]1([H])O2)/C(/C)=C/[C@@H]1CC[C@@H](O)[C@H](OC)C1)=O)=O)=O)O)C.O |t:30,&1:1,3,5,13,17,18,20,25,33,36,39,45,48,50,r|

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: KD4201200
HazardClass: 6.1
PackingGroup: III
HS Code: 2934990002
Toxicity: LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001926
Product name: Tacrolimus monohydrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001926
Price: $601
Updated: 2024/03/01

Sigma-Aldrich

Product number: F4679
Product name: FK-506 monohydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $271
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1642802
Product name: Tacrolimus
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100MG
Price: $1480
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1642802
Product name: Tacrolimus
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 150mg
Price: $1590
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001933
Product name: Tacrolimus for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0001933
Price: $212
Updated: 2023/06/20

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Tacrolimus Monohydrate Chemical Properties,Usage,Production

Uses

immune suppressant, antifungal

Uses

FK-506 monohydrate has been used:

as an immunosuppressive agent in coculture medium to study the effect of immunologic reaction
as a calcineurin inhibitor, in anhydrous Me₂SO solution
to treat retinal pigment epithelial cells to measure possible cytotoxicity

Definition

ChEBI: A hydrate that is the monohydrate form of tacrolimus.

Biological Activity

Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .

Biochem/physiol Actions

FK-506 also appears to inhibit Na+/Ca2+ exchange. FK-506 and its derivatives demonstrate significant neurodegenerative activity. This property seems to arise via different mechanisms. FK-506 is also useful in treating ophthalmologic complications such as corneal graft rejection, uveoretinitis and allergen induced conjunctivitis.

Safety Profile

A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.

Tacrolimus Monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tacrolimus Monohydrate Suppliers

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View Lastest Price from Tacrolimus Monohydrate manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Tacrolimus Monohydrate 109581-93-3
Price: US $30.00-25.00/KG
Min. Order: 1KG
Purity: 99.50%
Supply Ability: 20tons
Release date: 2023-07-13

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tacrolimus monohydrate 109581-93-3
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%-102%
Supply Ability: 500G
Release date: 2021-06-09

Weijer International Trade (Hebei) Co., Ltd

Product: Tacrolimus 109581-93-3
Price: US $50.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 20tons
Release date: 2023-03-16

109581-93-3, Tacrolimus MonohydrateRelated Search:

TacroliMus Methyl Acryl Aldehyde Δ23-FK-506 8-EpitacroliMus Tacrolimus N-LAUROYL-L-ALANINE Tacrolimus Monohydrate Ethyl1-butyl-2-piperidinecarbxylate Ascomycin N-LAUROYLSARCOSINE H-HOMOPRO-OME HCL 1-(2-methylpiperidin-1-yl)acetone

FK-506

15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-

TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone

Tacrolimus (150 mg)

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-

Tacrolimus monohydrate

FK-506 monohydrate, >=98%

Tacrolimus /FK506 monohydrate

Tacrolimus Monohydrate CAS 109581-93-3

,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-

18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*

3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,

tacrolimushydrate

tsukubaenolidehydrate

FK-506 MONOHYDRATE

Tacarolimus

15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-te

FK506 Monohydrate[Tacrolimus Hydrate]

135175

CS-1308

FK 506 monohydrate, Tacrolimus

Tacrolimus monohydroate

TacrolimusMonohydrate&gt

Tacrolimus monohydrate CRS

FR900506 monohydrate

Tacrolimus monohydrate (Fujimycin monohydrate

[3R[E(1S,3S,4S)

Tacrolimus monohydrate (Y0001926)

Tacrolimus (1642802)

Lecithin Impurity 9 (L-α-Phosphatidylinositol)

Tacrolimus USP/IP/PH.Eur

Tacrolimus Reference Standard

109581-93-3

C44H69NO12H2O

Cell Signaling and Neuroscience

Kinase/Phosphatase Biology

Protein Phosphatase 2B (Calcineurin/PP2B)

Serine/Threonine Phosphatase Inhibitors

BioChemical

Cell Biology

Signalling