1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE

Product Name: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
CAS No.: 4430-35-7
Chemical Name: 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE
Synonyms: 6-MITC;6-HITC;6-MITC; 6 MITC; 6MITC;6-METHYLSULFINYLHEXYL ISOTHIOCYANATE;1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE;Hexane, 1-isothiocyanato-6-(methylsulfinyl)-;6-(Methylsulfinyl)hexyl isothiocyanate (6-MITC), tumor cell proliferation inhibitor
CBNumber: CB4774237
Molecular Formula: C8H15NOS2
Formula Weight: 205.34
MOL File: Mol file

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1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Property

Boiling point:: 385.9±25.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: Refrigerator, under inert atmosphere
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Oil
color: Colourless to Pale Yellow
LogP: 0.959 (est)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3554
Product name: 6-(Methylsulfinyl)hexyl isothiocyanate
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $83.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3554
Product name: 6-(Methylsulfinyl)hexyl isothiocyanate
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $336
Updated: 2025/07/31

Cayman Chemical

Product number: 19638
Product name: 6-Methylsulfinylhexyl Isothiocyanate
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19638
Product name: 6-Methylsulfinylhexyl Isothiocyanate
Purity: ≥98%
Packaging: 5mg
Price: $122
Updated: 2024/03/01

Cayman Chemical

Product number: 19638
Product name: 6-Methylsulfinylhexyl Isothiocyanate
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

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1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Chemical Properties,Usage,Production

Description

6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities. It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 μM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607; IC₅₀ = 21.9 μM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC₅₀ = 43.7 μM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinson''s disease induced by 6-OHDA . 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.

Uses

6-(Methylsulfinyl)hexyl isothiocyanate derived from Wasabia japonica was discovered as an inhibitor of glycogen synthase kinase-3β.

Definition

ChEBI: 1-isothiocyanato-6-(methylsulfinyl)hexane is a sulfoxide.

in vivo

Hesperin (6-Methylsulfinylhexyl isothiocyanate, 6-MSITC) activates Nrf2 and induces phase II enzyme genes but this induction is absent in Nrf2-null mice, suggesting that Hesperin is a potential activator of the Nrf2/ARE-dependent detoxification pathway. To determine whether Hesperin ameliorates hepatic steatosis and iron accumulation, wild-type and Nrf2-null mice are fed the following diets for 12 weeks: 1) control diet, 2) high-fat diet (HFD), 3) HFD plus Hesperin (10 mg/kg/day ip), 4) HFD for 6 weeks followed by an iron-supplemented HFD for 6 weeks (HFD/Iron), 5) HFD/Iron plus Hesperin. The HFD increased hepatic triglycerides in both genotypes and Hesperin suppress increased hepatic triglycerides in wild-type mice but do not reduce these triglycerides in Nrf2-null mice^[1].

References

[1] TOSHIRO NOSHITA . Anti-nitric oxide production activity of isothiocyanates correlates with their polar surface area rather than their lipophilicity[J]. European Journal of Medicinal Chemistry, 2009, 44 12: Pages 4931-4936. DOI: 10.1016/j.ejmech.2009.08.005
[2] YASUJIRO MORIMITSU . Antiplatelet and anticancer isothiocyanates in Japanese domestic horseradish, Wasabi[J]. Mechanisms of Ageing and Development, 2000, 116 2: Pages 125-134. DOI: 10.1016/s0047-6374(00)00114-7
[3] TAKAHIRO NOMURA PHD . Selective sensitivity to wasabi-derived 6-(methylsulfinyl)hexyl isothiocyanate of human breast cancer and melanoma cell lines studied in vitro[J]. Cancer Epidemiology, 2005, 29 2: Pages 155-160. DOI: 10.1016/j.cdp.2004.07.010
[4] FABIANA MORRONI . Neuroprotection by 6-(methylsulfinyl)hexyl isothiocyanate in a 6-hydroxydopamine mouse model of Parkinson?s disease[J]. Brain Research, 2014, 1589: Pages 93-104. DOI: 10.1016/j.brainres.2014.09.033
[5] YOKO FUKE PHD . Preventive effect of oral administration of 6-(methylsulfinyl)hexyl isothiocyanate derived from wasabi (Wasabia japonica Matsum) against pulmonary metastasis of B16-BL6 mouse melanoma cells[J]. Cancer Epidemiology, 2006, 30 2: Pages 174-179. DOI: 10.1016/j.cdp.2005.10.005

1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE Suppliers

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4430-35-7, 1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANERelated Search:

6-METHYLSULFINYLHEXYL ISOTHIOCYANATE

1-ISOTHIOCYANATO-6-(METHYLSULFINYL)-HEXANE

6-HITC

6-MITC

6-MITC; 6 MITC; 6MITC

Hexane, 1-isothiocyanato-6-(methylsulfinyl)-

6-(Methylsulfinyl)hexyl isothiocyanate (6-MITC), tumor cell proliferation inhibitor

4430-35-7

C8H15NOS2

Aliphatics, Sulfur & Selenium Compounds