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GALANTHAMINONE

Product Name
GALANTHAMINONE
CAS No.
510-77-0
Chemical Name
GALANTHAMINONE
Synonyms
Narwedine;(4aS;8aS)-;Narwedin);-Narwedine;(-)-Narwedine;Galantaminone;GALANTHAMINONE;Galanthaminonel;Galantamine Impurity A
CBNumber
CB4774651
Molecular Formula
C17H19NO3
Formula Weight
285.34
MOL File
510-77-0.mol
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GALANTHAMINONE Property

Melting point:
175-180°C (dec.)
Boiling point:
397.4±42.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO : 10 mg/mL (35.05 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
Cryst.
pka
7.84±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C17H19NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,14H,7-10H2,1-2H3/t14-,17-/m0/s1
InChIKey
QENVUHCAYXAROT-YOEHRIQHSA-N
SMILES
N1(C)CC2=CC=C(OC)C3O[C@]4([H])[C@@](C=CC(=O)C4)(C2=3)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
G188550
Product name
Galanthaminone
Packaging
2mg
Price
$120
Updated
2021/12/16
TRC
Product number
G188550
Product name
Galanthaminone
Packaging
10mg
Price
$270
Updated
2021/12/16
TRC
Product number
G188550
Product name
Galanthaminone
Packaging
50mg
Price
$1100
Updated
2021/12/16
AK Scientific
Product number
9478AL
Product name
Galanthaminone
Packaging
25mg
Price
$1298
Updated
2021/12/16
Biosynth Carbosynth
Product number
FG23641
Product name
Galanthaminone
Packaging
50mg
Price
$1550
Updated
2021/12/16
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GALANTHAMINONE Chemical Properties,Usage,Production

Description

This alkaloid occurs in several families of the Amaryllidaceae and is obtained as colourless prisms when crystallized from Me2CO. It is dextrorotatory with [α]25D + 100° (c 0.2, CHC13). It forms a crystalline picrate, m.p. 123°C; a methiodide, m.p. 195-6°C and a semicarbazone, indicative of a keto group, m.p. 240-1 °c (dec.).

Chemical Properties

White to Off-White

Uses

A metabolite of Galanthamine, a selective acetylcholinesterase inhibitor

Uses

Narwedine is the biogenetic precursor of galanthamine, has been studied as a respiratory stimulator. It increases the amplitude and decreases the frequency of cardiac contractions and would therefore be of value in reducing blood loss during surgery. It also inhibits the action of narcotics and hypnotics, and increases the analgesic effect of morphine as well as the pharmacological effects of caffeine, carbazole, arecoline, and nicotine.

Definition

ChEBI: Narwedine is a benzazepine.

target

AChR | IL Receptor

References

Boit, Dapke, Beitner., Chem. Ber., 90,2197 (1957)

GALANTHAMINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GALANTHAMINONE manufacturers

Henan Fengda Chemical Co., Ltd
Product
GALANTHAMINONE 510-77-0
Price
US $35.00-1.10/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-19
Dideu Industries Group Limited
Product
GALANTHAMINONE 510-77-0
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27
Career Henan Chemical Co
Product
GALANTHAMINONE 510-77-0
Price
US $2.00/KG
Min. Order
1g
Purity
98%MIN
Supply Ability
ASK
Release date
2020-01-07

510-77-0, GALANTHAMINONERelated Search:

6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one, 4a,5,9,10,11,12-hexahydro-3-methoxy-, (4aS,8aS)- Galanthamine-N-oxide Memantine (-)-Huperzine A Donepezil Galanthaminium, 7-methyl-, iodide Epigalanthamine N-Oxide ENT- GALANTHAMINE Dihydrogalanthamine EPI-GALANTHAMINE Galantamine Hydrobromide TetrahydrogalantaMine N-DESMETHYLGALANTHAMINE GALANTHAMINONE Galanthamine

  • GALANTHAMINONE
  • Narwedine
  • (4aS
  • 8aS)-
  • (4aS,8aS)-4a,5,9,10,11,12-Hexahydro-3-Methoxy-11-Methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-one
  • GalantaMine interMediate ((-)-Narwedine)
  • GalantaMinone (GalantaMine IMpurity A)
  • 6H-Benzofuro[3a,3,2-ef][2]benzazepin-6-one,4a,5,9,10,11,12-hexahydro-3-Methoxy-11-Methyl-, (4aS,8aS)-
  • Galanthaminone Narwedine
  • Galantamine Hydrobromide Lycoremine
  • (4AS,8aS)-3-methoxy-11-methyl-9,10,11,12-tetrahydro-4aH-benzo[2,3]benzofuro[4,3-cd]azepin-6(5H
  • Galantamine EP impurity A -F
  • Narwedin)
  • Galantamine EP impurity A
  • N6-p-Methoxyphenyladenosin
  • (-)-Narwedine 99.8% min
  • Galantamine Impurity 1（Galantamine EP Impurity A）
  • (-)-Narwedine Galnthaminone Narwedin
  • Galantamine EP Impurity A (Galantaminone)
  • (-)-Narwedine
  • Galantaminone
  • GALANTHAMINONE USP/EP/BP
  • Galantamine hydrobromide EP Impurity A
  • (4AS,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-benzo[2,3]benzofuro[4,3-cd]azepin-6-one
  • (4aS,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one (narwedine)
  • Narwedine (6CI, 7CI, 8CI)
  • -Narwedine
  • GALANTHAMINONE Impurity
  • Galanthamine EP Impurity A
  • GALANTHAMINONE, 10 mM in DMSO
  • (4aS,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12- hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6- one
  • Phenylgalantamine impurity 24
  • Galanthaminonel
  • Galantamine hydrobromide Imp. A (EP): (4aS,8aS)-3-methoxy-11-methyl-4a,5,9,10,11,12-hexahydro-6H-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-one (narwedine)
  • Galantamine Impurity A
  • 510-77-0
  • 19453
  • 1953/4/4
  • raw materials
  • Various Metabolites and Impurities
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites
  • Pharmaceuticals