ChemicalBook > CAS DataBase List > 4-Fluoro-2-methylphenylboronic acid
4-Fluoro-2-methylphenylboronic acid
- Product Name
- 4-Fluoro-2-methylphenylboronic acid
- CAS No.
- 139911-29-8
- Chemical Name
- 4-Fluoro-2-methylphenylboronic acid
- Synonyms
- AKOS BRN-0102;4-FLUORO-O-TOLYLBORONIC ACID;4-Fluoro-2-Methylphenylboronic;4-Fluoro-2-methylphenylboronicaci;4-FLUORO-2-METHYLPHENYLBORONIC ACID;4-Fluoro-2-Methylbenzenboronic acid;2-METHYL-4-FLUOROPHENYLBORONIC ACID;4-FLUORO-2-METHYLBENZENEBORONIC ACID;2-methyl-4-fluorobenzeneboronic acid;4-Fluoro-2-methylbenzeneboronicacid98%
- CBNumber
- CB4779843
- Molecular Formula
- C7H8BFO2
- Formula Weight
- 153.95
- MOL File
- 139911-29-8.mol
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4-Fluoro-2-methylphenylboronic acid Property
- Melting point:
- 191-196 °C(lit.)
- Boiling point:
- 277.4±50.0 °C(Predicted)
- Density
- 1.20±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
- pka
- 8.75±0.58(Predicted)
- form
- Powder
- color
- White to off-white
- InChI
- InChI=1S/C7H8BFO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,10-11H,1H3
- InChIKey
- IQMLIVUHMSIOQP-UHFFFAOYSA-N
- SMILES
- B(C1=CC=C(F)C=C1C)(O)O
- CAS DataBase Reference
- 139911-29-8(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37/39-26-36/37/39-27
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- F0666
- Product name
- 4-Fluoro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0666
- Product name
- 4-Fluoro-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $239
- Updated
- 2025/07/31
American Custom Chemicals Corporation
- Product number
- BOR0001527
- Product name
- 4-FLUORO-2-METHYL BENZENE BORONIC ACID
- Purity
- 95.00%
- Packaging
- 25G
- Price
- $1522.29
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 6760-3-Y1
- Product name
- 4-Fluoro-2-methylbenzeneboronic acid
- Purity
- 98%
- Packaging
- 100g
- Price
- $308
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-W008943
- Product name
- 4-Fluoro-2-methylphenylboronic acid
- Purity
- 99.86%
- Packaging
- 100g
- Price
- $226
- Updated
- 2021/12/16
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4-Fluoro-2-methylphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white to off-white powder
Uses
suzuki reaction
Synthesis
5419-55-6
452-63-1
139911-29-8
The general procedure for the synthesis of 4-fluoro-2-methylphenylboronic acid from triisopropyl borate and 2-bromo-5-fluorotoluene was carried out as follows: 2-bromo-5-fluorotoluene (250 g) was dissolved in a solvent mixture of tetrahydrofuran (250 ml) and n-hexane (250 ml) under dry conditions, and cooled to -78 °C. At this temperature, n-butyllithium (991.5 ml) was slowly added dropwise and the reaction temperature was maintained in an ice bath. After the dropwise addition, the reaction mixture was stirred for 1 hour. Subsequently, triisopropyl borate (373.11 g) was added dropwise and stirring was continued at -78°C for 1 hour. After completion of the reaction, the reaction mixture was diluted with aqueous sodium hydroxide solution and then washed with n-heptane. The pH of the aqueous layer was adjusted to 2-3 with hydrochloric acid followed by extraction with ethyl acetate. The organic layers were combined and concentrated under vacuum. The concentrated product was dissolved in ethyl acetate at about 40 °C and n-heptane was added to promote crystallization, resulting in 4-fluoro-2-methylphenylboronic acid. The yield was 61.5% and the HPLC purity was 99.00%.
References
[1] Patent: WO2017/125835, 2017, A1. Location in patent: Paragraph 00117
4-Fluoro-2-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2-methylphenylboronic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- 4-Fluoro-2-methylphenylboronic acid 139911-29-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- 4-Fluoro-2-methylphenylboronic acid 139911-29-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg;5kg;100kg
- Release date
- 2019-07-04
139911-29-8, 4-Fluoro-2-methylphenylboronic acidRelated Search:
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