ChemicalBook > CAS DataBase List > PRATENSEIN

PRATENSEIN

Product Name: PRATENSEIN
CAS No.: 2284-31-3
Chemical Name: PRATENSEIN
Synonyms: PRALENREIN;PRATENSEIN;PATCHOULI ALCOHOL (RG);OROBOL 4'-METHYL ETHER;Pratensein, 10 mM in DMSO;5,7,3'-Trihydroxy-4'-methoxyisoflavone;4'-METHOXY-3',5,7-TRIHYDROXYISOFLAVONE;5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one;5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-
CBNumber: CB4783091
Molecular Formula: C16H12O6
Formula Weight: 300.26
MOL File: 2284-31-3.mol

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PRATENSEIN Property

Melting point:: 272-273°
Boiling point:: 576.7±50.0 °C(Predicted)
Density: 1.512±0.06 g/cm3(Predicted)
pka: 6.45±0.20(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C16H12O6/c1-21-13-3-2-8(4-11(13)18)10-7-22-14-6-9(17)5-12(19)15(14)16(10)20/h2-7,17-19H,1H3
InChIKey: FPIOBTBNRZPWJW-UHFFFAOYSA-N
SMILES: C1OC2=CC(O)=CC(O)=C2C(=O)C=1C1=CC=C(OC)C(O)=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AvaChem

Product number: 4397
Product name: Pratensein
Packaging: 1mg
Price: $119
Updated: 2021/12/16

AvaChem

Product number: 4397
Product name: Pratensein
Packaging: 5mg
Price: $290
Updated: 2021/12/16

Arctom

Product number: CFN90805
Product name: Pratensein
Purity: ≥98%
Packaging: 5mg
Price: $418
Updated: 2021/12/16

AvaChem

Product number: 4397
Product name: Pratensein
Packaging: 10mg
Price: $490
Updated: 2021/12/16

AvaChem

Product number: 4397
Product name: Pratensein
Packaging: 20mg
Price: $690
Updated: 2021/12/16

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PRATENSEIN Chemical Properties,Usage,Production

Uses

Pratensein, a flavonoid, ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels[1].

Definition

ChEBI: A member of the class of 7-hydroxyisoflavones in which isoflavone is substituted by hydroxy groups at the 5, 7, and 3' positions, and by a methoxy group at the 4' position.

in vivo

Pratensein significantly attenuates neuronal degeneration and apoptosis in hippocampus. The over-expression in IL-1β and TNF-α as well as the extensive astrogliosis and microgliosis in hippocampus induced by Aβ1-42 are significantly reduced following administration of Pratensein. Pratensein treatment significantly suppresses the activation of NF-κB in hippocampus. Pratensein is able to increase the levels of synaptophysin and brain-derived neurotrophic factor (BDNF)^[1].
Pratensein (20 mg/kg; p.o.; once daily for 3 weeks) ameliorates learning and memory deficits in Aβ1-42 rat model of Alzheimer’s disease^[1].

Animal Model:	Male 10-week old Wistar rats^[1]
Dosage:	20 mg/kg
Administration:	P.o.; once daily for 3 weeks
Result:	The spatial learning and memory ability of rats was improved.

References

[1] Liang C, et al. Pratensein ameliorates β-amyloid-induced cognitive impairment in rats via reducing oxidative damage and restoring synapse and BDNF levels. Neurosci Lett. 2015;592:48-53. DOI:10.1016/j.neulet.2015.03.003

PRATENSEIN Preparation Products And Raw materials

Raw materials

Preparation Products

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2284-31-3, PRATENSEINRelated Search:

PRATENSEIN(P) 5,7,3',4'-TETRAMETHOXYISOFLAVONE 5-HYDROXYDEQUELIN 5,7-DIHYDROXY-3-(2,4,5-TRIMETHOXY-PHENYL)-CHROMEN-4-ONE 5-HYDROXY-7-METHOXY-3-(2,4,5-TRIMETHOXY-PHENYL)-CHROMEN-4-ONE ISOPOMIFERIN-3',4'-DIMETHYL ETHER OROBOL 7,3',4'-TRIMETHYL ETHER OROBOL 7,4'-DIMETHYL ETHER POMIFERIN-3',4'-DIMETHYL ETHER 5-METHOXYMETHYLACICERONE 3'-O-METHYLPRATENSEIN IRISFLORENTIN PRATENSEIN 5,7-DIHYDROXY-3',4'-METHYLENEDIOXYISOFLAVONE 5-METHOXYDURMILLONE

5,7,3'-Trihydroxy-4'-methoxyisoflavone

5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

PATCHOULI ALCOHOL (RG)

4'-METHOXY-3',5,7-TRIHYDROXYISOFLAVONE

PRATENSEIN

PRALENREIN

OROBOL 4'-METHYL ETHER

Inhibitor,Nuclear factor-kappaB,Nuclear factor-κB,cognitive,inhibit,BDNF,synapse,Pratensein,damage,impairment,NF-κB,oxidative

4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-

Pratensein, 10 mM in DMSO

5,7-Dihydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one

2284-31-3

Iso-Flavones