DCZ0415

Product Name: DCZ0415
CAS No.: 2242470-43-3
Chemical Name: DCZ0415
Synonyms: DCZ0415;DCZ0415, 10 mM in DMSO;2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione;4,6-Ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 4,4a,5,5a,6,6a-hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-;DCZ0415,DCZ 0415,Apoptosis,inhibit,nonhomologous,Nuclear factor-κB,TRIP13,Inhibitor,joining,DCZ-0415,end,drug-resistant,myeloma,repair,anti-myeloma,Nuclear factor-kappaB,NF-κB
CBNumber: CB48029461
Molecular Formula: C23H20N2O2
Formula Weight: 356.42
MOL File: 2242470-43-3.mol

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DCZ0415 Property

Boiling point:: 624.2±55.0 °C(Predicted)
Density: 1.319±0.06 g/cm3(Predicted)
solubility: DMSO:62.5(Max Conc. mg/mL);175.35(Max Conc. mM)
form: Solid
pka: 5.80±0.10(Predicted)
color: Off-white to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3216
Product name: DCZ0415
Purity: 99%
Packaging: 5mg
Price: $93.5
Updated: 2021/12/16

ChemScene

Product number: CS-0109396
Product name: DCZ0415
Purity: 99.96%
Packaging: 5mg
Price: $145
Updated: 2021/12/16

Axon Medchem

Product number: Axon3216
Product name: DCZ0415
Purity: 99%
Packaging: 2x5mg
Price: $154
Updated: 2021/12/16

ChemScene

Product number: CS-0109396
Product name: DCZ0415
Purity: 99.96%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0109396
Product name: DCZ0415
Purity: 99.96%
Packaging: 25mg
Price: $530
Updated: 2021/12/16

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DCZ0415 Chemical Properties,Usage,Production

Description

DCZ0415 is a novel inhibitor of TRIP13, suppressing multiple myeloma progression.

Uses

DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients[1].

in vivo

DCZ0415 (ip; 50 mg/kg/day for 14 days) significantly reduces the growth of MM cells-induced tumors in immune-deficient mice^[1].

Animal Model:	Nude mice (6-weeks-old) with H929 775 cells^[1]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection; every day for 14 days
Result:	Significantly reduced the growth of MM cells-induced tumors.

target

DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity.

IC 50

NF-κB

References

[1] Wang Y, et al. A Small Molecule Inhibitor Targeting TRIP13 suppresses multiple myeloma progression. Cancer Res. 2019 Nov 15. pii: canres.3987.2018. DOI:10.1158/0008-5472.CAN-18-3987

DCZ0415 Preparation Products And Raw materials

Raw materials

Preparation Products

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DCZ0415 Suppliers

China 35 United States 4 Global 39

Shanghai Beckham Medical Technology Co., Ltd

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2242470-43-3, DCZ0415Related Search:

DCZ0415

DCZ0415,DCZ 0415,Apoptosis,inhibit,nonhomologous,Nuclear factor-κB,TRIP13,Inhibitor,joining,DCZ-0415,end,drug-resistant,myeloma,repair,anti-myeloma,Nuclear factor-kappaB,NF-κB

4,6-Ethenocycloprop[f]isoindole-1,3(2H,3aH)-dione, 4,4a,5,5a,6,6a-hexahydro-2-[4-(4-pyridinylmethyl)phenyl]-

2-(4-(Pyridin-4-ylmethyl)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione

DCZ0415, 10 mM in DMSO

2242470-43-3