ChemicalBook > CAS DataBase List > 2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL

2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL

Product Name
2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL
CAS No.
496062-16-9
Chemical Name
2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL
Synonyms
4-Thiazoleethanol,2-bromo-5-methyl-;2-(2-bromo-5-methylthiazol-4-yl)ethanol;2-BroMo-4-(2-hydroxyethyl)-5-Methylthiazole;2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL
CBNumber
CB4803768
Molecular Formula
C6H8BrNOS
Formula Weight
222.1
MOL File
496062-16-9.mol
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2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL Property

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B292205
Product name
2-Bromo-4-(2-hydroxyethyl)-5-methylthiazole
Packaging
100mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
5474AJ
Product name
2-Bromo-4-(2-hydroxyethyl)-5-methylthiazole
Packaging
250mg
Price
$172
Updated
2021/12/16
AK Scientific
Product number
5474AJ
Product name
2-Bromo-4-(2-hydroxyethyl)-5-methylthiazole
Packaging
1g
Price
$320
Updated
2021/12/16
AK Scientific
Product number
5474AJ
Product name
2-Bromo-4-(2-hydroxyethyl)-5-methylthiazole
Packaging
5g
Price
$1130
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0010280
Product name
2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL
Purity
95.00%
Packaging
1G
Price
$8483.19
Updated
2021/12/16
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2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL Chemical Properties,Usage,Production

Synthesis

496062-15-8

496062-16-9

Example 173 Synthesis of 2-(2-bromo-5-methyl-1,3-thiazol-4-yl)ethanol To a solution of methyl 2-(2-bromo-5-methylthiazol-4-yl)acetate (3.80 g, 15.2 mmol) prepared in Example 172 in dichloromethane (100 mL) was slowly added diisobutylaluminum hydride (DIBAL-H, 33.4 mL, 33.4 mmol, 1.0 M toluene solution) at -78°C. After 15 min of reaction, the reaction system was slowly warmed to 0 °C and stirring was continued for 90 min. Subsequently, 2N aqueous hydrochloric acid solution (50 mL) was added dropwise to quench the excess DIBAL-H. The organic phase was separated and the aqueous phase was extracted with dichloromethane (2 x 200 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Purification of the residue by rapid column chromatography on silica gel (eluent ratio 5:2 hexane/ethyl acetate) afforded the target product 2-(2-bromo-5-methyl-1,3-thiazol-4-yl)ethanol (2.5 g, 74% yield) as a yellow oil, which solidified on standing. Product characterization data: Molecular formula: C6H8BrNOS LC-MS: retention time 1.38 min, [M+H]+ m/z 221.0 1H NMR (CDCl3): δ 2.31 (s, 3H), 2.82 (t, 2H), 2.90-3.00 (wide s, 1H), 3.89 (t, 2H).

References

[1] Patent: US2003/216391, 2003, A1
[2] Patent: US2018/153859, 2018, A1. Location in patent: Paragraph 0552; 0553
[3] Patent: US2018/153860, 2018, A1. Location in patent: Paragraph 0554; 0555

2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL Suppliers

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496062-16-9, 2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOLRelated Search:

2-(2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ETHANOL METHYL (2-BROMO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE

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  • 4-Thiazoleethanol,2-bromo-5-methyl-
  • 2-BroMo-4-(2-hydroxyethyl)-5-Methylthiazole
  • 2-(2-bromo-5-methylthiazol-4-yl)ethanol
  • 496062-16-9