BCN-PEG3-VC-PFP ester
- Product Name
- BCN-PEG3-VC-PFP ester
- CAS No.
- 2353409-45-5
- Chemical Name
- BCN-PEG3-VC-PFP ester
- Synonyms
- BCN-PEG3-VC-PFP ester;endo BCN-PEG3-VC-PFP Ester;L-Ornithine, N-[16-(1R,8S)-bicyclo[6.1.0]non-4-yn-9-yl-1,14-dioxo-4,7,10,15-tetraoxa-13-azahexadec-1-yl]-L-valyl-N5-(aminocarbonyl)-, 2,3,4,5,6-pentafluorophenyl ester
- CBNumber
- CB48054667
- Molecular Formula
- C37H50F5N5O10
- Formula Weight
- 819.81
- MOL File
- 2353409-45-5.mol
BCN-PEG3-VC-PFP ester Property
- Boiling point:
- 925.6±65.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- pka
- 12.05±0.46(Predicted)
- InChIKey
- ODFSIYMVJDIAIS-COWKONOXSA-N
- SMILES
- C(OC1=C(F)C(F)=C(F)C(F)=C1F)(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCNC(=O)OCC1[C@@]2([H])[C@]1([H])CCC#CCC2
N-Bromosuccinimide Price
- Product number
- BP-24334
- Product name
- BCN-PEG3-VC-PFPEster
- Purity
- 96%
- Packaging
- 100mg
- Price
- $840
- Updated
- 2021/12/16
BCN-PEG3-VC-PFP ester Chemical Properties,Usage,Production
Description
BCN-PEG3-VC-PFP Ester is a cleavable ADC linker. PFP ester can be reactive with amine-bearing molecule to form stable amide bond. The Val-Cit will specifically be cleaved by Cathepsin B. As this enzyme is only present in the lysosome, the ADC payload will be released only in the cell. The BCN group can react with azide-tagged biomolecules.
Uses
BCN-PEG3-VC-PFP ester is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. BCN-PEG3-VC-PFP ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
IC 50
Protease Cleavable Linker; Cleavable Linker
References
[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268
BCN-PEG3-VC-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BCN-PEG3-VC-PFP ester manufacturers
- Product
- endo BCN-PEG3-VC-PFP Ester 2353409-45-5
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >95.00%
- Supply Ability
- 100mg
- Release date
- 2024-03-29