Pam3Cys-Ser-(Lys)4 TFA
- Product Name
- Pam3Cys-Ser-(Lys)4 TFA
- CAS No.
- 112208-01-2
- Chemical Name
- Pam3Cys-Ser-(Lys)4 TFA
- Synonyms
- Pam3CSK4 TFA;Pam3Cys-Ser-(Lys)4 TFA;Pam3CSK4 TFA (112208-00-1 free base);S-(2,3-Bis(palmitoyloxy)propyl)-N-palmitoyl-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine tri(trifluoroacetate salt);Pam3CSK4 TFA (112208001 free base),Pam3CSK4,Toll-like Receptor (TLR),Pam-3CSK4 TFA (112208-00-1 free base),Inhibitor,inhibit,Pam3CSK4 TFA (112208 00 1 free base)
- CBNumber
- CB48054874
- Molecular Formula
- C83H157F3N10O15S
- Formula Weight
- 1624.28
- MOL File
- 112208-01-2.mol
Pam3Cys-Ser-(Lys)4 TFA Property
- storage temp.
- -20°C, away from moisture
- solubility
- DMSO : ≥ 50 mg/mL (26.99 mM)
- form
- Solid
- color
- White to off-white
Pam3Cys-Ser-(Lys)4 TFA Chemical Properties,Usage,Production
Uses
Pam3CSK4 TFA is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2[1].
in vivo
Pam3CSK4 (5 mg/kg; i.p.; once a day for 9 days) alters brain, spleen and liver weights in neonatal mice[3].
| Animal Model: | Time-mated pregnant C57BL/6 wild-type mice; B6.129-Tlr2tm1Kir/J (TLR2 -deficient) mice[3] |
| Dosage: | 5 mg/kg |
| Administration: | Intraperitoneally (i.p.); once a day for 9 days |
| Result: | After repeated administration from postnatal day (PND3) to PND11, brain weight was decreased compared with endotoxin-free saline-treated animals at PND12. Decreased volume of cerebral gray matter, white matter in the forebrain and cerebellar molecular layer that was accompanied by an increase in spleen and liver weight at PND12. |
IC 50
TLR1; TLR2
References
[1] Irvine KL, et al. The molecular basis for recognition of bacterial ligands at equine TLR2, TLR1 and TLR6. Vet Res. 2013 Jul 4;44:50. DOI:10.1186/1297-9716-44-50
[2] Chen Y, et al. TLR2 agonist Pam3CSK4 enhances the antibacterial functions of GM-CSF induced neutrophils to methicillin-resistant Staphylococcus aureus. Microb Pathog. 2019 May;130:204-212. DOI:10.1016/j.micpath.2019.02.030
[3] Du X, et al. Systemic stimulation of TLR2 impairs neonatal mouse brain development. PLoS One. 2011 May 6;6(5):e19583. DOI:10.1371/journal.pone.0019583
Pam3Cys-Ser-(Lys)4 TFA Preparation Products And Raw materials
Raw materials
Preparation Products
Pam3Cys-Ser-(Lys)4 TFA Suppliers
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 42446
- Advantage
- 60
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
- Country
- China
- ProdList
- 29760
- Advantage
- 68
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 14948
- Advantage
- 58
- Tel
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 7408
- Advantage
- 58
- Tel
- 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10503
- Advantage
- 58
- Tel
- 159-00573766 18018507602
- 394643792@qq.com
- Country
- China
- ProdList
- 4328
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24961
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6979
- Advantage
- 58