(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid

Product Name: (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid
CAS No.: 2264011-98-3
Chemical Name: (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid
Synonyms: Fmoc-GGFG-Glycolic acid;Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH;Fmoc-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide;(S)-10-Benzyl-16-(Fmoc-amino)-6,9,12,15-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-1-oic Acid;(S)-11-benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid
CBNumber: CB48082187
Molecular Formula: C33H35N5O9
Formula Weight: 645.67
MOL File: 2264011-98-3.mol

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(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid Property

Boiling point:: 1107.2±65.0 °C(Predicted)
Density: 1.339±0.06 g/cm3(Predicted)
form: Solid
pka: 3.20±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid Chemical Properties,Usage,Production

Uses

Fmoc-GGFG-Glycolic acid ((S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid) is a cleavable ADC linker with an Fmoc group and a terminal carboxylic acid group.

Preparation

benzyl(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid (150 mg，0.2 mmol), methanol (8mL), and DMF (1mL) were added to the single-mouth bottle, and then Pd/C (45mg, 5%) was added for hydrogenation reaction for 2 hours. After filtration, 1.8 mL of diethylamine was added to the filtrate, and the mixture was stirred at room temperature for 2 hours. The crude product is obtained by reducing pressure concentration. Finally, (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid was obtained after purification.

(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid Suppliers

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2264011-98-3, (S)-11-Benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acidRelated Search:

(S)-11-benzyl-1-(9H-fluoren-9-yl)-3,6,9,12,15-pentaoxo-2,18-dioxa-4,7,10,13,16-pentaazaicosan-20-oic acid

Fmoc-GGFG-Glycolic acid

(S)-10-Benzyl-16-(Fmoc-amino)-6,9,12,15-tetraoxo-3-oxa-5,8,11,14-tetraazahexadecan-1-oic Acid

Fmoc-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Fmoc-Gly-Gly-L-Phe-N-[(carboxymethoxy)methyl]Glycinamide

2264011-98-3

C33H35N5O9