N1-Methyl-Pseudouridine-5'-Triphosphate

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N1-Methyl-Pseudouridine-5'-Triphosphate

Color Form

Product Name: N1-Methyl-Pseudouridine-5'-Triphosphate
CAS No.: 1428903-59-6
Chemical Name: N1-Methyl-Pseudouridine-5'-Triphosphate
Synonyms: abs60156;N1-Me-pUTP;Pseudo-UTP-Na3;N1 -Me-Pseudo UTP;N1-Methylpseudo-UTP;N1-Methy-Pseudo-UTP;Cytidine Impurity 9;N1-Me-pUTP Tris salt;N1-Me-pUTP Sodium Salt;N1-Me-pUTP sodium solution
CBNumber: CB48099851
Molecular Formula: C10H17N2O15P3
Formula Weight: 498.17
MOL File: 1428903-59-6.mol

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N1-Methyl-Pseudouridine-5'-Triphosphate Property

Density: 2.010±0.06 g/cm3(Predicted)
pka: 0.97±0.50(Predicted)
InChI: InChI=1/C10H17N2O15P3/c1-12-2-4(9(15)11-10(12)16)8-7(14)6(13)5(25-8)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-8,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19)/t5-,6-,7-,8+/s3
InChIKey: OLRONOIBERDKRE-CAYFCZNJNA-N
SMILES: O[C@@H]1[C@@H]([C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O[C@H]1C1=CN(C)C(=O)NC1=O)O |&1:1,2,3,19,r|

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Hazard and Precautionary Statements (GHS)

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N1-Methyl-Pseudouridine-5'-Triphosphate Chemical Properties,Usage,Production

Color

N1-Methyl-Pseudouridine-5'-Triphosphate is a colorless to slightly yellow.

Form

N1-Methyl-Pseudouridine-5'-Triphosphate is a solution in water.

Description

N1-Methyl-Pseudouridine-5'-Triphosphate, also known as N1-Methylpseudouridine-5'-Triphosphate, N1meΨTP, m1ΨTP, or 1-Methyl-PseudoUridine Phosphoramidite, is a modified NTP for incorporation into messenger RNAs (mRNA) using T7 RNA Polymerase. Incorporation of N1-Methylpseudouridine can reduce the immunogenicity of the resulting mRNA. In addition, the free form of the compound is prone to instability; it is advisable to consider the stable salt form (N1-Methylpseudouridine-5′-triphosphate trisodium) that retains the same biological activity.

Uses

1-Methylpseudouridine-5'-triphosphate Sodium Salt is a salt analogue of 1-Methylpseudouridine-5'-triphosphate, which can be used to optimize the cardiac delivery of modified mRNA

Advantages

The substitution of U with N1-Methyl-Pseudouridine-5'-Triphosphate (m1Ψ) not only bypasses immune response induced cytotoxicity, but also substantially enhances the effectiveness of both types of switches. The m1Ψ substitution induced higher protein expression of mRNA than other modified bases, allowing clearer detection of signals and better fold-change between ON and OFF states of the switches. In addition, the m1Ψ substitution enhanced the sensitivity and performance of synthetic RNA circuit composed of both miRNA- and RBP-sensing switches[1].

References

[1] Callum J C Parr. “N 1-Methylpseudouridine substitution enhances the performance of synthetic mRNA switches in cells.” Nucleic Acids Research 48 6 (2020): e35.

N1-Methyl-Pseudouridine-5'-Triphosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from N1-Methyl-Pseudouridine-5'-Triphosphate manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Pseudo-UTP-Na3 1428903-59-6
Price: US $0.00/ml
Min. Order: 100ml
Purity: HPLC：≥90.0%
Supply Ability: 500L
Release date: 2024-02-06

WUHAN FORTUNA CHEMICAL CO., LTD

Product: N1-Methyl-Pseudouridine-5'-Triphosphate 1428903-59-6
Price: US $0.00/KG
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Purity: 98.0%
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Release date: 2023-01-13

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N1-methyl-Pseudo-UTP
Price: US $0.00/ml
Min. Order: 100ml
Purity: ≥99%(HPLC)
Supply Ability: 20000L
Release date: 2023-03-09

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