Seco-DUBA

Product Name: Seco-DUBA
CAS No.: 1227961-59-2
Chemical Name: Seco-DUBA
Synonyms: SYD985;Seco-DUBA;Benzamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxy-
CBNumber: CB48129965
Molecular Formula: C29H23ClN4O4
Formula Weight: 526.97
MOL File: 1227961-59-2.mol

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Seco-DUBA Property

Density: 1.47±0.1 g/cm3(Predicted)
pka: 8.08±0.15(Predicted)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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Seco-DUBA Chemical Properties,Usage,Production

Uses

Seco-DUBA is a inactive prodrug form of duocarmycin (DUBA) containing two hydroxyl groups, which can each be used for coupling to an antibody via a linker. Seco-DUBA can be used in the synthesis of antibody-drug conjugates (ADCs).

Definition

Duocarmycins (DUMs; A, B1, B2, C1, C2, D1, D2 and SA) are members of an extremely potent group of antitumor antibiotics isolated from Streptomyces sp. The pharmacophore consists of a cyclopropa[c]pyrrolo[3,2-e]indole (CPI) moiety. DUMs B1, B2, C1, C2, D1 and D2 were a seco-type of DUM A and chemically more stable than DUM A[1].

in vitro

Seco-DUBA (SK-BR-3 cells; 0.0001 pM~0.01 nM; 144 hours) dose-dependent reduces cell viability and shows equally potent and efficacious as DUBA[1]. Seco-DUBA causes SK-BR-3 (IC50=0.09), SK-OV-3 (IC50=0.43), and SW620 (IC50=0.09) cells to exhibit highly sensitive.
Seco-DUBA (89 μg/kg; i.v.) is likely converted to DUBA almost instantaneously[2].

target

Humanized IgG1, HER-2
Humanized IgG1, 5 T4
Humanized IgG1, CD22
Mouse IgG1; CD56

References

[1] Choi T, et al. Structural Influence of Indole C5-N-Substitutents on the Cytotoxicity of seco-Duocarmycin Analogs. Archives of Pharmacal Research, 2011; 34: 357–367.
[2] Elgersma R, et al. Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985. Molecular Pharmaceutics, 2015; 12: 1813–1835.

Seco-DUBA Preparation Products And Raw materials

Raw materials

Preparation Products

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Seco-DUBA Suppliers

China 13 United States 1 Global 14

Levena (Suzhou) Biopharma Co., Ltd.

Tel: 0512-81877925 051281877925
Email: info@levena.cn
Country: China
ProdList: 48
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

Shanghai Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: 021-58955996
Email: info@chemexpress.com
Country: China
ProdList: 815
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: +86-027-59232304 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9956
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Shanghai Easy CDMO Co.,Ltd

Tel: 021-61734564
Email: August@easycdmo.com
Country: China
ProdList: 10030
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 14760821013 13564957716
Email: 1816280386@qq.com
Country: China
ProdList: 7889
Advantage: 58

Hubei Soren Technology Co., Ltd

Tel: 0-13419562052 13419562052
Email: wwmlyb@163.com
Country: China
ProdList: 2860
Advantage: 58

Jilin Chinese Academy of Sciences-yanshen Technology

Tel: 18143011203
Email: ET-market@chemextension.com
Country: China
ProdList: 25868
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Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Email: 2853877583@QQ.com
Country: China
ProdList: 7829
Advantage: 58

1227961-59-2, Seco-DUBARelated Search:

Benzamide, N-[2-[[(1S)-1-(chloromethyl)-1,2-dihydro-5-hydroxy-9-methyl-3H-benz[e]indol-3-yl]carbonyl]imidazo[1,2-a]pyridin-6-yl]-4-hydroxy-

Seco-DUBA

SYD985

1227961-59-2

C29H23ClN4O4