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FERULENOL

Product Name
FERULENOL
CAS No.
6805-34-1
Chemical Name
FERULENOL
Synonyms
FERULENOL;FERULENOL USP/EP/BP;Ferulenol, ATP synthesis inhibitor;4-Hydroxy-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-coumarin;4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-
CBNumber
CB4819349
Molecular Formula
C24H30O3
Formula Weight
366.49
MOL File
6805-34-1.mol
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FERULENOL Property

Melting point:
55-56℃
Boiling point:
525.3±50.0 °C(Predicted)
Density 
1.070±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
4.50±1.00(Predicted)
form 
Off-white solid.
color 
White to off-white
LogP
7.730 (est)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19568
Product name
Ferulenol
Purity
≥95%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
19568
Product name
Ferulenol
Purity
≥95%
Packaging
5mg
Price
$157
Updated
2024/03/01
Cayman Chemical
Product number
19568
Product name
Ferulenol
Purity
≥95%
Packaging
10mg
Price
$274
Updated
2024/03/01
Usbiological
Product number
044790
Product name
Ferulenol
Packaging
1mg
Price
$282
Updated
2021/12/16
TRC
Product number
F309003
Product name
Ferulenol
Packaging
1mg
Price
$45
Updated
2021/12/16
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FERULENOL Chemical Properties,Usage,Production

Uses

Ferulenol is antibiotic useful against mycobacteria similar to taxol.

Biological Activity

ferulenol is a prenylated 4-hydroxycoumarin derivative from ferula communis var. genuine with haemorrhagic action [1]. it has been demonstrated that ferulenol exihibits potent antimycobacterial activity [2].

in vitro

ferulenol stimulated tubulin polymerization in the absence of gtp, with a less extensive polymerization profile at 100 pm concentration. ferulenol decreased radiolabeled colchicine bound by tubulin in a dose-dependent manner. ferulenol altered the normal nuclear morphology of mcf-7 cells. treatment with ferulenol (100 nm and 1 μm) for 24h induced a dose-dependent reduction of cell viability [3]

in vivo

in albino mice, the acute ld50s of ferulenol by single po or ip were 2,100 and 319 mg/kg bw, respectively. three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages. male mice were more sensitive to intoxication than females [4].

storage

+4°C

References

[1] lamnaouer d, bodo b, martin m t, et al. ferulenol and ω-hydroxyferulenol, toxic coumarins from ferula communis var. genuina[j]. phytochemistry, 1987, 26(6): 1613-1615.
[2] e. mamoci, i. cavoski, v. simone, et al. chemical composition and in vitro activity of plant extracts from ferula communis and dittrichia viscosa against postharvest fungi. molecules 16(3), 2609-2625 (2011).
[3] bocca c, gabriel l, bozzo f, et al. microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol[j]. planta medica, 2002, 68(12): 1135-1137.
[4] fraigui o, lamnaouer d, faouzi m y. acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from ferula communis l[j]. veterinary and human toxicology, 2002, 44(1): 5-7.

FERULENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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FERULENOL Suppliers

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6805-34-1, FERULENOLRelated Search:

1-Hexanol farnesylacetic acid FERULENOL

  • FERULENOL
  • 4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-2H-1-benzopyran-2-one
  • 4-Hydroxy-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-coumarin
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-
  • FERULENOL USP/EP/BP
  • Ferulenol, ATP synthesis inhibitor
  • 6805-34-1