FERULENOL

Product Name: FERULENOL
CAS No.: 6805-34-1
Chemical Name: FERULENOL
Synonyms: FERULENOL;FERULENOL USP/EP/BP;4-Hydroxy-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-coumarin;4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-
CBNumber: CB4819349
Molecular Formula: C24H30O3
Formula Weight: 366.49
MOL File: 6805-34-1.mol

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FERULENOL Property

Melting point:: 55-56℃
Boiling point:: 525.3±50.0 °C(Predicted)
Density: 1.070±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 4.50±1.00(Predicted)
form: Off-white solid.
color: White to off-white
LogP: 7.730 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19568
Product name: Ferulenol
Purity: ≥95%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 19568
Product name: Ferulenol
Purity: ≥95%
Packaging: 5mg
Price: $157
Updated: 2024/03/01

Cayman Chemical

Product number: 19568
Product name: Ferulenol
Purity: ≥95%
Packaging: 10mg
Price: $274
Updated: 2024/03/01

Usbiological

Product number: 044790
Product name: Ferulenol
Packaging: 1mg
Price: $282
Updated: 2021/12/16

TRC

Product number: F309003
Product name: Ferulenol
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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FERULENOL Chemical Properties,Usage,Production

Uses

Ferulenol is antibiotic useful against mycobacteria similar to taxol.

Biological Activity

ferulenol is a prenylated 4-hydroxycoumarin derivative from ferula communis var. genuine with haemorrhagic action [1]. it has been demonstrated that ferulenol exihibits potent antimycobacterial activity [2].

in vitro

ferulenol stimulated tubulin polymerization in the absence of gtp, with a less extensive polymerization profile at 100 pm concentration. ferulenol decreased radiolabeled colchicine bound by tubulin in a dose-dependent manner. ferulenol altered the normal nuclear morphology of mcf-7 cells. treatment with ferulenol (100 nm and 1 μm) for 24h induced a dose-dependent reduction of cell viability [3]

in vivo

in albino mice, the acute ld50s of ferulenol by single po or ip were 2,100 and 319 mg/kg bw, respectively. three days after ferulenol administration, dosed animals showed hypoprothrombinemia with internal and external hemorrhages. male mice were more sensitive to intoxication than females [4].

storage

+4°C

References

[1] lamnaouer d, bodo b, martin m t, et al. ferulenol and ω-hydroxyferulenol, toxic coumarins from ferula communis var. genuina[j]. phytochemistry, 1987, 26(6): 1613-1615.
[2] e. mamoci, i. cavoski, v. simone, et al. chemical composition and in vitro activity of plant extracts from ferula communis and dittrichia viscosa against postharvest fungi. molecules 16(3), 2609-2625 (2011).
[3] bocca c, gabriel l, bozzo f, et al. microtubule-interacting activity and cytotoxicity of the prenylated coumarin ferulenol[j]. planta medica, 2002, 68(12): 1135-1137.
[4] fraigui o, lamnaouer d, faouzi m y. acute toxicity of ferulenol, a 4-hydroxycoumarin isolated from ferula communis l[j]. veterinary and human toxicology, 2002, 44(1): 5-7.

FERULENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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FERULENOL Suppliers

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6805-34-1, FERULENOLRelated Search:

1-Hexanol farnesylacetic acid FERULENOL

FERULENOL

4-Hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl]-2H-1-benzopyran-2-one

4-Hydroxy-3-(3,7,11-trimethyl-2,6,10-dodecatrienyl)-coumarin

2H-1-Benzopyran-2-one, 4-hydroxy-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-

FERULENOL USP/EP/BP

6805-34-1