L-692,585

Product Name: L-692,585
CAS No.: 145455-35-2
Chemical Name: L-692,585
Synonyms: 585;L-692;L-692,585;L 692585,L692585;3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide;3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide;Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
CBNumber: CB4819480
Molecular Formula: C32H37N7O3
Formula Weight: 567.68
MOL File: 145455-35-2.mol

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L-692,585 Property

storage temp.: Desiccate at -20°C
solubility: Soluble to 100 mM in DMSO and to 25 mM in ethanol
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2261
Product name: L-692,585
Purity: ≥98%(HPLC)
Packaging: 10
Price: $235
Updated: 2021/12/16

TRC

Product number: L692630
Product name: L-692,585
Packaging: 1mg
Price: $195
Updated: 2021/12/16

Usbiological

Product number: 255638
Product name: L-692,585
Packaging: 10mg
Price: $573
Updated: 2021/12/16

ApexBio Technology

Product number: B6994
Product name: L-692,585
Packaging: 10mg
Price: $448
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0009978
Product name: L-692,585
Purity: 95.00%
Packaging: 5MG
Price: $502.25
Updated: 2021/12/16

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L-692,585 Chemical Properties,Usage,Production

Uses

L-692,585 shows potent and selective GH-secretory activity in several species including human.

Definition

ChEBI: 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide is a peptide.

Biological Activity

Highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (K i = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

in vivo

L-692585 (0.01-0.1 mg/kg; i.v. once daily for 2 weeks) increases peak plasma GH levels and total GH release^[3].
L-692585 (0.005-0.1 mg/kg; a single i.v.) significantly increases peak GH concentrations 4.3-fold at a dose of 0.005 mg/kg, 7-fold at a dose of 0.02 mg/kg, and 21-fold at a dose of 0.10 mg/kg in vivo^[3].

Animal Model:	Beagles (1-1.5 years old ; weighting 8.5-16.0 kg)^[3]
Dosage:	0.01, 0.1 mg/kg
Administration:	I.v. once daily for 2 weeks
Result:	Increased the peak plasma GH levels and total GH release on days 1, 8 and 15 in a dose-dependent manner, and no desensitization was evident.

storage

Desiccate at -20°C

L-692,585 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-692,585 Suppliers

China 14 Germany 1 United Kingdom 1 United States 7 USA 1 Global 24

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Shanghai Fine Biotech Co.，Ltd

Tel: 18221172427
Email: sale@fine-biotech.com
Country: China
ProdList: 2767
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

TargetMol Chemicals Inc.

Tel: +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 19962
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Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

145455-35-2, L-692,585Related Search:

1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one 3-Amino-2,3,4,5-Tetrahydro-1H-1-benzazepin-2-one 1-BENZYL-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE 1H-1-BENZAZEPIN-3-AMINE, 2,3,4,5-TETRAHYDRO- 2,3,4,5-Tetrahydro-1H-benzo[b]azepine N-(1-METHYL-3-PHENYLPROPYL)ISOVALERAMIDE 5-BIPHENYL-2-YL-2H-TETRAZOLE (R)-3-AMINO-2,3,4,5-TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE 2H-1-BENZAZEPIN-2-ONE, 1,3,4,5-TETRAHYDRO-1-METHYL- L-692,585 5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE

L-692,585

L-692

3-[[(2R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide

3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4,5-dihydro-3H-1-benzazepin-3-yl]butanamide

Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-

585

L 692585,L692585

145455-35-2

C32H37N7O3