L-96

Product Name: L-96
CAS No.: 1159408-61-3
Chemical Name: L-96
Synonyms: L-96;GalNAc-L96-SA;L-96-Succinic Acid;GalNAc-L96-Succinate;GalNAc-L96 free base;4-(((3R,5S)-1-(1-(((2R,3R..;NND-22812、GalNac-L96 free base;Butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galac...;1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate;4-(((3R,5S)-1-(1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-16,16-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)pyrrolidin-3-yl)oxy)-4-oxobutanoic acid
CBNumber: CB48197164
Molecular Formula: C121H179N11O45
Formula Weight: 2507.8
MOL File: 1159408-61-3.mol

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L-96 Property

Boiling point:: 1889.4±65.0 °C(Predicted)
Density: 1.31±0.1 g/cm3(Predicted)
solubility: DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
pka: 4.39±0.17(Predicted)
InChIKey: XKEQVRGRWUKTIZ-GKBCKKAWNA-N

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Hazard and Precautionary Statements (GHS)

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L-96 Chemical Properties,Usage,Production

Uses

GalNAc-L96 free base is a triantennary GalNAc ligand that can be used for the synthesis of GalNAc-siRNA[1]. GalNAc is a ligand of ASGPR (asialoglycoprotein receptor).

References

[1] Anna Clua, et al. Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes. Molecules. 2022 Jun 20;27(12):3944. DOI:10.3390/molecules27123944
[2] JAYAPRAKASH K. NAIR. Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing[J]. Journal of the American Chemical Society, 2014, 136 49: 16958-16961. DOI: 10.1021/ja505986a

L-96 Preparation Products And Raw materials

Raw materials

Preparation Products

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L-96 Suppliers

China 53 United States 1 Global 54

Tianjin Orilife Biopharma Co.,Ltd.

Tel: 15032236037; 17602299400
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Wuhu Huaren Science and Technology Co., Ltd.

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Changsha Morning Shine Co., Ltd.

Tel: 189-75832125 13397510867
Email: BD@csmspharm.com
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Tianjin Scaxchem Limited Compnay

Tel: 18020011318 18630949181
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Shanghai Hope Chem Co., Ltd.，

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Shenzhen HwaGen Pharmaceutical Co.,Ltd

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Zhengzhou Alfachem Co., Ltd.

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Wuhu Huaren Science and Technology Co., Ltd.

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Perida Pharmaceutical Co., Ltd.

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Shanghai Yu Ben Biotechnology Co., Ltd.

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1159408-61-3, L-96Related Search:

Butanedioic acid, 1-[(3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galac...

4-(((3R,5S)-1-(1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-16,16-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)pyrrolidin-3-yl)oxy)-4-oxobutanoic acid

L-96

4-(((3R,5S)-1-(1-(((2R,3R..

GalNAc-L96-SA

L-96-Succinic Acid

GalNAc-L96-Succinate

1-[(3R,5S)-5-[[Bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-[1,12,19,25-tetraoxo-14,14-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-29-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-16-oxa-13,20,24-triazanonacos-1-yl]-3-pyrrolidinyl] butanedioate

GalNAc-L96 free base

4-{[(3R,5S)-1-(11-[(1,3-bis(2-[(3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxepan-2-yl]oxy}pentanamido)propyl)carbamoyl]ethoxy)-2-[(2-[(3-(5-{[(2R,3R,4R,5R,6R)-4,5-bis(acetyloxy)-6-[(acetyloxy)methyl]-3-acetamidooxepan-2-yl]oxy}pentanamido)propyl)carbamoyl]ethoxy)methyl]propan-2-yl)carbamoyl]undecanoyl)-5-[(bis(4-methoxyphenyl)(phenyl)methoxy)methyl]pyrrolidin-3-yl]oxy}-4-oxobutanoic acid

NND-22812、GalNac-L96 free base

1159408-61-3

C121H179N11O45

GalNAc

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