1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-

Product Name: 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-
CAS No.: 1978371-23-1
Chemical Name: 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-
Synonyms: Keverprazan;P-CAB agent 2;Ornidazole Impurity 46;1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-;1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine
CBNumber: CB48365361
Molecular Formula: C22H25FN2O4S
Formula Weight: 432.51
MOL File: 1978371-23-1.mol

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1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- Property

Boiling point:: 587.5±60.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
form: Oil
pka: 9.18±0.10(Predicted)
color: Light brown to brown

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Hazard and Precautionary Statements (GHS)

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1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- Chemical Properties,Usage,Production

Uses

P-CAB agent 2 is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].

in vivo

P-CAB agent 2 (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats^[1].
P-CAB agent 2 (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats^[1].

Animal Model:	180-220 g, SPF grade, male SD rats^[1]
Dosage:	2 mg/kg
Administration:	P.o.; once
Result:	Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.

References

[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.

1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl- Suppliers

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1978371-23-1, 1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-Related Search:

AR-AO 14418-d3 3,4-Dimethoxybenzaldehyde-d3 4-HYDROXY-3-METHOXYBENZALDEHYDE-D3 Ethyl-d5 Vanillin PyridostigMine-d6 BroMide

1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-

P-CAB agent 2

Ornidazole Impurity 46

Keverprazan

1-(5-(2-Fluorophenyl)-1-((3-(3-methoxypropoxy)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine

1978371-23-1