CALP2
- Product Name
- CALP2
- CAS No.
- 261969-04-4
- Chemical Name
- CALP2
- Synonyms
- CALP2;CALP2 trifluoroacetate salt;L-Phenylalanine, L-valyl-L-lysyl-L-phenylalanylglycyl-L-valylglycyl-L-phenylalanyl-L-lysyl-L-valyl-L-methionyl-L-valyl- (9CI)
- CBNumber
- CB4837235
- Molecular Formula
- C68H104N14O13S
- Formula Weight
- 1357.7
- MOL File
- 261969-04-4.mol
CALP2 Property
- Boiling point:
- 1602.4±65.0 °C(Predicted)
- Density
- 1.205±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- Soluble to 0.50 mg/ml in 10% ethanol / water
- form
- Powder
- pka
- 3.50±0.10(Predicted)
- Sequence
- Val-Lys-Phe-Gly-Val-Gly-Phe-Lys-Val-Met-Val-Phe
N-Bromosuccinimide Price
- Product number
- 254864
- Product name
- CALP2
- Packaging
- 1mg
- Price
- $403
- Updated
- 2021/12/16
- Product number
- PEP0004459
- Product name
- CALP2
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.2
- Updated
- 2021/12/16
- Product number
- B5289
- Product name
- CALP2
- Packaging
- 1mg
- Price
- $234
- Updated
- 2021/12/16
CALP2 Chemical Properties,Usage,Production
Uses
CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 μM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages[1][2][3][4].
References
[1] R Houtman, et al. Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J Immunol. 2001 Jan 15;166(2):861-7. DOI:10.4049/jimmunol.166.2.861
[2] R Ten Broeke, et al. Calcium sensors as new therapeutic targets for airway hyperresponsiveness and asthma. FASEB J. 2001 Aug;15(10):1831-3. DOI:10.1096/fj.01-0018fje
[3] Robert Ten Broeke, et al. Specific modulation of calmodulin activity induces a dramatic production of superoxide by alveolar macrophages. Lab Invest. 2004 Jan;84(1):29-40. DOI:10.1038/sj.labinvest.3700002
[4] M Villain, et al. De novo design of peptides targeted to the EF hands of calmodulin. J Biol Chem. 2000 Jan 28;275(4):2676-85. DOI:10.1074/jbc.275.4.2676
CALP2 Preparation Products And Raw materials
Raw materials
Preparation Products
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