6-CHLORO-8-HYDROXYQUINOLINE
- Product Name
- 6-CHLORO-8-HYDROXYQUINOLINE
- CAS No.
- 18119-24-9
- Chemical Name
- 6-CHLORO-8-HYDROXYQUINOLINE
- Synonyms
- 8-chloroquinolin-6-ol;6-Quinolinol, 8-chloro-;8-Chloro-6-hydroxyquinoline;6-CHLORO-8-HYDROXYQUINOLINE
- CBNumber
- CB4837725
- Molecular Formula
- C9H6ClNO
- Formula Weight
- 179.6
- MOL File
- 18119-24-9.mol
6-CHLORO-8-HYDROXYQUINOLINE Property
- Melting point:
- 237-238 °C (decomp)(Solv: ethanol (64-17-5))
- Boiling point:
- 343.5±22.0 °C(Predicted)
- Density
- 1.412±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 8.11±0.40(Predicted)
- color
- Grey
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR943283
- Product name
- 8-Chloroquinolin-6-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3014AL
- Product name
- 6-Chloro-8-hydroxyquinoline
- Packaging
- 10g
- Price
- $752
- Updated
- 2021/12/16
- Product number
- 3014AL
- Product name
- 6-Chloro-8-hydroxyquinoline
- Packaging
- 25g
- Price
- $1387
- Updated
- 2021/12/16
- Product number
- A128422
- Product name
- 8-Chloroquinolin-6-ol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- A128422
- Product name
- 8-Chloroquinolin-6-ol
- Purity
- 97%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
6-CHLORO-8-HYDROXYQUINOLINE Chemical Properties,Usage,Production
Synthesis
52671-64-4
56-81-5
18119-24-9
Step 4: In a 500mL three-necked flask equipped with a mechanical stirrer and reflux condenser, a solution of ferrous sulfate (2.0 g), 4-amino-3-chlorophenol hydrochloride (6.4 g, commercially available), nitrobenzene (2.9 mL), and boric acid (3.0 g) in glycerol (16 g) were added sequentially. Subsequently, concentrated sulfuric acid (9 mL) was added slowly and dropwise under cooling conditions. The ice bath was removed and replaced with an oil bath, and the reaction mixture was cautiously heated to 120 °C, maintained at this temperature for 2 h, and then heated up to 150 °C with continued stirring for 20 h. The reaction mixture was then heated up to 150 °C with continued stirring. Upon completion of the reaction, the mixture was cooled, decanted onto crushed ice and the resulting solution was neutralized with K2CO3. The product precipitated as a light brown solid, which was separated by filtration, washed sequentially with water and hexane, and finally dried in a vacuum oven at 35 °C overnight to obtain 7 g (77% yield) of the target product 8-chloro-6-hydroxyquinoline. Mass spectrum (ES) m/z (relative intensity): 180 ([M+H]+, 100).
References
[1] Patent: US2007/299083, 2007, A1. Location in patent: Page/Page column 14
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 10, p. 4066 - 4084
[3] Patent: US2007/27160, 2007, A1. Location in patent: Page/Page column 43
6-CHLORO-8-HYDROXYQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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