ChemicalBook > CAS DataBase List > 6-chloro-2-methyl-2H-indazol-5-amine

6-chloro-2-methyl-2H-indazol-5-amine

Application

Product Name: 6-chloro-2-methyl-2H-indazol-5-amine
CAS No.: 1893125-36-4
Chemical Name: 6-chloro-2-methyl-2H-indazol-5-amine
Synonyms: Ensitrelvir Intermediate;2H-Indazol-5-amine, 6-chloro-2-methyl-;S-217622-001;6-chloro-2-methyl-indazol-5-amine;6-gas-2-methyl-21-inch call-5-blad;6-chloro-2-methyl-2H-indazol-5-amine;5-Amino-6-chloro-2-methyl-2H-indazole;6-Chloro-2-methyl-2H-indazol-5-ylamine;6-chlorine-2-methyl-2h-Indazole-5-amine;Atracurium Impurity 61 (Atracurium Besilate EP Impurity D)
CBNumber: CB48392288
Molecular Formula: C8H8ClN3
Formula Weight: 181.62
MOL File: 1893125-36-4.mol

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6-chloro-2-methyl-2H-indazol-5-amine Property

Boiling point:: 365.6±22.0 °C(Predicted)
Density: 1.45±0.1 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light
pka: 2.05±0.10(Predicted)
Appearance: Light brown to gray Solid
InChI: InChI=1S/C8H8ClN3/c1-12-4-5-2-7(10)6(9)3-8(5)11-12/h2-4H,10H2,1H3
InChIKey: YRZNRFJEBAPCCO-UHFFFAOYSA-N
SMILES: N1=C2C(C=C(N)C(Cl)=C2)=CN1C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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6-chloro-2-methyl-2H-indazol-5-amine Chemical Properties,Usage,Production

Application

6-Chloro-2-methyl-2H-indazole-5-amine possesses a variety of biological activities, including antitumor, antibacterial, anti-inflammatory, and osteoporosis treatment. Therefore, it has attracted widespread attention in the field of medicinal chemistry and has great research potential and value.

Synthesis

A suspension of 6-Chloro-1-methyl-5-nitro-1H-indazole (700 mg, 3.31 mmol), NH4CI (1 .59g, 29.77mmol) & Fe powder (1.66g, 29.77mmol) in a mixture of EtOH: Water (15mL: 15mL) was heated to 80°C for 6h. After 6h, TLC analysis indicated the formation of a polar spot (Ninhydrin positive). Then, the reaction mixture was cooled to RT and filtered through the celite bed; the celite bed was washed with EtOH (50mL); the filtrate was concentrated under reduced pressure to give a crude product. The crude product was purified by column chromatography (silica gel 100-200mesh) using 25% EtOAc in petroleum ether as an eluent to give 6- chloro-2-methyl-2H-indazol-5-amine (quantitative yield) as an off-white solid.

6-chloro-2-methyl-2H-indazol-5-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-chloro-2-methyl-2H-indazol-5-amine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 6-Chloro-2-methyl-2H-indazol-5-amine 1893125-36-4
Price: US $8.80-2.20/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-27

PNP Biotech Co. Ltd

Product: 6-chloro-2-methyl-2H-Indazol-5-amine 1893125-36-4
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-10-20

Hebei Xinsheng New Material Technology Co., LTD.

Product: 6-chloro-2-methyl-2H-indazol-5-amine 1893125-36-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2023-09-15

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