4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Product Name: 4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CAS No.: 412293-91-5
Chemical Name: 4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
Synonyms: tert-Butyl 4-(pyrimidin-2-yloxy);1-Boc-4-(PyriMidin-2-yloxy)piperidine;4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylic acid, 4-(2-pyrimidinyloxy)-, 1,1-dimethylethyl ester
CBNumber: CB4840941
Molecular Formula: C14H21N3O3
Formula Weight: 279.33
MOL File: 412293-91-5.mol

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4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Property

storage temp.: 2-8°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B699863
Product name: tert-Butyl4-(pyrimidin-2-yloxy)piperidine-1-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140456
Product name: tert-Butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate
Packaging: 2g
Price: $93
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140456
Product name: tert-Butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate
Packaging: 5G
Price: $186
Updated: 2021/12/16

Matrix Scientific

Product number: 074495
Product name: 1-Boc-4-(Pyrimidin-2-yloxy)piperidine
Purity: 95+%
Packaging: 1g
Price: $208
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140456
Product name: tert-Butyl 4-(pyrimidin-2-yloxy)piperidine-1-carboxylate
Packaging: 10g
Price: $323.8
Updated: 2021/12/16

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4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production

Synthesis

1722-12-9

109384-19-2

412293-91-5

General procedure for the synthesis of tert-butyl 4-(pyrimidin-2-yloxy)-piperidine-1-carboxylate from 2-chloropyrimidine and N-Boc-4-hydroxypiperidine: N-Boc-4-hydroxypiperidine (10 g, 50 mmol) was dissolved in tetrahydrofuran (200 mL) and the solution was cooled to 5 °C. Under stirring, sodium hydride (60% mineral oil dispersion, 2.5 g, 65 mmol) was added in batches and stirring was continued for 30 min keeping the reaction temperature at 5 °C. Subsequently, 2-chloropyrimidine (11.4 g, 99 mmol) was added and the reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure. The concentrated residue was partitioned between ethyl acetate and water. The organic layer was separated, dried with anhydrous magnesium sulfate and subsequently concentrated under reduced pressure. Finally, the residue was recrystallized in diisopropyl ether (50 mL) to afford tert-butyl 4-(pyrimidin-2-yloxy)-piperidine-1-carboxylate in 68% (9.5 g) yield.

References

[1] Patent: WO2005/105779, 2005, A1. Location in patent: Page/Page column 46

4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

China 23 India 1 United Kingdom 1 United States 8 Global 33

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412293-91-5, 4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTERRelated Search:

Propylthiouracil 2-(Piperidin-4-yloxy)pyrimidine 4-(5-Bromopyrimidin-2-yloxy)piperidine-1-carboxylic acid tert-butyl 4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(PYRIMIDIN-2-YLOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1-Boc-4-(PyriMidin-2-yloxy)piperidine

tert-Butyl 4-(pyrimidin-2-yloxy)

1-Piperidinecarboxylic acid, 4-(2-pyrimidinyloxy)-, 1,1-dimethylethyl ester

412293-91-5