1-Hexadecanol

ChemicalBook > CAS DataBase List > 1-Hexadecanol

Product Name: 1-Hexadecanol
CAS No.: 36653-82-4
Chemical Name: 1-Hexadecanol
Synonyms: CETYL ALCOHOL;HEXADECANOL;HEXADECAN-1-OL;Ethol;CETANOL;Lipocol C;n-Hexadecanol;Cetylic alcohol;Cetylol;Cetyl alcohol NF
CBNumber: CB4853561
Molecular Formula: C16H34O
Formula Weight: 242.44
MOL File: 36653-82-4.mol

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1-Hexadecanol Property

Melting point:: 48-50 °C (lit.)
Boiling point:: 179-181 °C/10 mmHg (lit.)
Density: 0.818 g/mL at 25 °C (lit.)
vapor density: 8.34 (vs air)
vapor pressure: <0.01 mm Hg ( 43 °C)
refractive index: nD79 1.4283
FEMA: 2554 | 1-HEXADECANOL
Flash point:: 275 °F
storage temp.: Store below +30°C.
solubility: Soluble in alcohol, chloroform, ether
pka: 15.20±0.10(Predicted)
form: Powder, Flakes or Pellets
color: White to off-white
Odor: at 100.00 %. waxy clean greasy floral oily
Odor Type: waxy
explosive limit: 8%
Water Solubility: insoluble
Merck: 14,2028
JECFA Number: 114
BRN: 1748475
Dielectric constant: 3.6（60℃）
Stability:: Stable. Incompatible with strong oxidizing agents, strong acids.
LogP: 6.7
CAS DataBase Reference: 36653-82-4(CAS DataBase Reference)
NIST Chemistry Reference: 1-Hexadecanol(36653-82-4)
EPA Substance Registry System: 1-Hexadecanol (36653-82-4)

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Safety

Hazard Codes: Xi
Risk Statements: 38-36/37/38
Safety Statements: 22-24/25-37
WGK Germany: -
RTECS: MM0225000
Autoignition Temperature: 483 °F
TSCA: Yes
HS Code: 29051700
Hazardous Substances Data: 36653-82-4(Hazardous Substances Data)
Toxicity: LD50 orally in Rabbit: > 2000 mg/kg LD50 dermal Rabbit > 2000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.18704
Product name: Cetyl alcohol
Purity: for synthesis
Packaging: 100g
Price: $29.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.18704
Product name: Cetyl alcohol
Purity: for synthesis
Packaging: 1kg
Price: $71
Updated: 2024/03/01

Sigma-Aldrich

Product number: 68824
Product name: Cetyl alcohol
Purity: analytical standard
Packaging: 1g
Price: $34.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 68824
Product name: Cetyl alcohol
Purity: analytical standard
Packaging: 5G
Price: $110
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1103003
Product name: Cetyl alcohol
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 100mg
Price: $474
Updated: 2024/03/01

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1-Hexadecanol Chemical Properties,Usage,Production

Description

1-Hexadecanol is a waxy white powder or flake form at room temperature, and is insoluble in water and soluble in alcohols and oils. Discovered by Chevrenl in 1913, It is one of the oldest known long-chain alcohol. It can be produced from the reduction of palmitic acid. 1-Hexadecanol may be contained in cosmetic and personal care products such as shampoos, creams and lotions. it is mainly used as an opacifier, emulsifier, and thickening agent that alter the thickness of the liquid, and increase and stabilize the foaming capacity.

Chemical Properties

Cetyl alcohol occurs as waxy, white flakes, granules, cubes, or castings. It has a faint characteristic odor and bland taste.

Originator

Hexadecyl alcohol,Esso Res. And Eng. Co.

Occurrence

Reported as a major constituent of spermaceti oil, where it is present chiefy as cetyl palmitate Also reported found in guava, peach, pear, kohlrabi, baked potato, mustard, Parmesan cheese, butter, milk powder, boiled egg, cooked chicken, roasted beef, beef fat, whiskies, tea, starfruit, mango, rice, licorice, kiwifruit, loquat, endive, shrimp, crab, clam, Cape gooseberry and pawpaw

Uses

1-Hexadecanol has been used in preparation of:
(±)-2-methoxyheptadecanoic acid (fatty acid)
high-chain fatty acid esters of 1-hexadecanol, novel organic phase change material for thermal energy storage
hexadecane (alkane) in the presence of membrane fraction of Vibrio furnissii M1

Uses

cetyl alcohol is a versatile ingredient that can serve as an emollient, emulsifier, thickener, binder, foam booster, or emulsion stabilizer, depending on the formulation and need. It is derived from coconut or palm oil as well as being synthetically manufactured. It is considered by some sources to be a non-comedogenic material.

Definition

ChEBI: 1-Hexadecanol is a long chain fatty alcohol that is hexadecane substituted by a hydroxy group at position 1. It is a synthetic, solid, fatty alcohol and nonionic surfactant. It is used as an emulsifying agent in pharmaceutical preparations.

Production Methods

Cetyl alcohol may be manufactured by a number of methods such as esterification and hydrogenolysis of fatty acids or by catalytic hydrogenation of the triglycerides obtained from coconut oil or tallow. Cetyl alcohol may be purified by crystallization and distillation.

Therapeutic Function

Pharmaceutic aid

Synthesis Reference(s)

The Journal of Organic Chemistry, 42, p. 512, 1977 DOI: 10.1021/jo00423a025
Synthetic Communications, 25, p. 1901, 1995 DOI: 10.1080/00397919508015865
Tetrahedron Letters, 24, p. 4485, 1983 DOI: 10.1016/S0040-4039(00)85933-X

General Description

1-Hexadecanol is a free fatty acid alcohol generally used as an emulsifier, emollient, opacifier and surfactant in cosmetics formulations.

Flammability and Explosibility

Not classified

Safety

Cetyl alcohol is mainly used in topical formulations, although it has also been used in oral and rectal preparations.
Cetyl alcohol has been associated with allergic delayed-type hypersensitivity reactions in patients with stasis dermatitis. Crosssensitization with cetostearyl alcohol, lanolin, and stearyl alcohol has also been reported. It has been suggested that hypersensitivity may be caused by impurities in commercial grades of cetyl alcohol since highly refined cetyl alcohol (99.5%) has not been associated with hypersensitivity reactions.
LD₅₀ (mouse, IP): 1.6 g/kg
LD₅₀ (mouse, oral): 3.2 g/kg
LD₅₀ (rat, IP): 1.6 g/kg
LD₅₀ (rat, oral): 5 g/kg

storage

Cetyl alcohol is stable in the presence of acids, alkalis, light, and air; it does not become rancid. It should be stored in a well-closed container in a cool, dry place.

Purification Methods

Crystallise the alcohol from aqueous EtOH or from cyclohexane. Alternatively purify it by zone refining. The purity can be checked by gas chromatography. [Beilstein 1 H 429, 1 I 219, 1 II 466, 1 III 1815, 1 IV 1876.]

Incompatibilities

Incompatible with strong oxidizing agents. Cetyl alcohol is responsible for lowering the melting point of ibuprofen, which results in sticking tendencies during the process of film coating ibuprofen crystals.

Regulatory Status

Included in the FDA Inactive Ingredients Database (ophthalmic preparations, oral capsules and tablets, otic and rectal preparations, topical aerosols, creams, emulsions, ointments and solutions, and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

1-Hexadecanol Preparation Products And Raw materials

Raw materials

Chemicals Chromatographic fixative Sodium borohydride Sodium hydroxide Detergent CETYL PALMITATE Palmitoyl chloride

Preparation Products

STEARYL TARTRATE 1-Bromohexadecane 1-IODOHEXADECANE 1-Chlorohexadecane Hexadecyl trimethyl ammonium bromide Miltefosine CETYL LACTATE

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View Lastest Price from 1-Hexadecanol manufacturers

Hebei Yime New Material Technology Co., Ltd.

Product: cetyl alcohol 36653-82-4
Price: US $15.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 10000kg/month
Release date: 2022-09-30

Hebei Yime New Material Technology Co., Ltd.

Product: 1-Hexadecanol 36653-82-4
Price: US $3.00/kg
Min. Order: 1000kg
Purity: 99
Supply Ability: 10000kg/day
Release date: 2023-11-09

Hebei Yime New Material Technology Co., Ltd.

Product: cetyl alcohol 36653-82-4
Price: US $3.00/KG
Min. Order: 1000KG
Purity: 99%
Supply Ability: 1000kg/day
Release date: 2023-11-09

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