ChemicalBook > CAS DataBase List > 1-Chloroisobutyl propionate

1-Chloroisobutyl propionate

Product Name
1-Chloroisobutyl propionate
CAS No.
58304-65-7
Chemical Name
1-Chloroisobutyl propionate
Synonyms
1-chloroisobutyl propionate;PROPIONIC ACID-1-CHLOROISOBUTYL;1-CHLOROISOBUTYL PROPIONATE,85+%;1-Chloro-2-Methylpropyl Propanoate;1-Propanol, 1-chloro-2-methyl-, propanoate;1-Propanol, 1-chloro-2-methyl-, 1-propanoate;1-Chloroisobutyl propionate (Technical Grade)
CBNumber
CB4854977
Molecular Formula
C7H13ClO2
Formula Weight
164.63
MOL File
58304-65-7.mol
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1-Chloroisobutyl propionate Property

Boiling point:
166.7°C
Density 
1.030
Flash point:
56°C
storage temp. 
2-8°C
solubility 
Chloroform
Appearance
Colorless to light yellow Liquid
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Safety

HS Code 
2915907098
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FC140870
Product name
1-Chloro-2-methylpropyl propionate
Packaging
100mg
Price
$51
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140870
Product name
1-Chloro-2-methylpropyl propionate
Packaging
250mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140870
Product name
1-Chloro-2-methylpropyl propionate
Packaging
500mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140870
Product name
1-Chloro-2-methylpropyl propionate
Packaging
1g
Price
$306.25
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140870
Product name
1-Chloro-2-methylpropyl propionate
Packaging
2g
Price
$520
Updated
2021/12/16
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1-Chloroisobutyl propionate Chemical Properties,Usage,Production

Uses

Intermediate in the preparation of Fosinopril (F727800) derivatives.

Synthesis

79-03-8

78-84-2

58304-65-7

Isobutyraldehyde (3 g, 41.6 mmol) was slowly added dropwise to propionyl chloride (3.85 g, 41.6 mmol) cooled to 0-5 °C under nitrogen protection, keeping the temperature in the range 0-5 °C. The reaction mixture was stirred continuously at this temperature for 4 hours. Upon completion of the reaction, the mixture was vacuum distilled at 50 °C to remove the volatile components, resulting in 2.59 g of a colorless liquid product, i.e., isobutyl propionyl-1-chloride (yield: 38%). The structure of the product was confirmed by 1H-NMR and 13C-NMR: 1H-NMR (CDCl3, 500MHz) δ 1.06 (t, J = 7.0Hz, 6H), 7.60 (t, J = 7.5Hz, 3H), 2.13-2.17 (m, 1H), 2.39 (q, J = 7.5Hz, 2H), 6.31 (d, J = 4.5 Hz, 1H); 13C-NMR (CDCl3, 125MHz) δ 8.66, 17.25, 17.36, 27.49, 35.19, 88.61, 172.16.

References

[1] Patent: US2008/125483, 2008, A1. Location in patent: Page/Page column 9
[2] Patent: WO2009/118580, 2009, A2. Location in patent: Page/Page column 23-24
[3] Patent: US2014/56849, 2014, A1. Location in patent: Paragraph 0306-0308
[4] Patent: CN103626765, 2016, B. Location in patent: Paragraph 0402; 0404; 0405
[5] Journal of the American Chemical Society, 1921, vol. 43, p. 665

1-Chloroisobutyl propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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58304-65-7, 1-Chloroisobutyl propionateRelated Search:

Calcium Propionate Isobutyl chloroformate Beclomethasone dipropionate TERT-BUTYL PROPIONATE Butyl levulinate Clobetasol propionate (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER t-butyl chloroformate Propionic acid Chloromethyl acetate 1-Chloroisobutyl propionate

  • 1-chloroisobutyl propionate
  • PROPIONIC ACID-1-CHLOROISOBUTYL
  • 1-CHLOROISOBUTYL PROPIONATE,85+%
  • 1-Chloro-2-Methylpropyl Propanoate
  • 1-Chloroisobutyl propionate (Technical Grade)
  • 1-Propanol, 1-chloro-2-methyl-, 1-propanoate
  • 1-Propanol, 1-chloro-2-methyl-, propanoate
  • 58304-65-7
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