Methicillin Sodium Salt
- Product Name
- Methicillin Sodium Salt
- CAS No.
- 132-92-3
- Chemical Name
- Methicillin Sodium Salt
- Synonyms
- meticillin sodium;Methicillin sodium;Sodium methicillin;Meticillin sodium salt;Methicillin sodium salt;METHICILLIN SODIUM USP/EP/BP;Methicillin Sodium Salt USP/EP/BP;Sodium (2,6-dimethoxyphenyl)penicillin;sodium 6-(2,6-dimethoxybenzamido)penicillanate;TIANFU-CHEM -sodium 6-(2,6-dimethoxybenzamido)penicillanate
- CBNumber
- CB4874973
- Molecular Formula
- C17H19N2NaO6S
- Formula Weight
- 402.39733
- MOL File
- 132-92-3.mol
Methicillin Sodium Salt Property
- Melting point:
- 196-197℃
- Boiling point:
- 640℃
- Flash point:
- >110°(230°F)
- storage temp.
- 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- powder
- color
- white to off-white
- Water Solubility
- Slightly soluble in acetone. Soluble in ethanol or water
- Sensitive
- Light Sensitive
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 2
- RTECS
- XH8950000
- Toxicity
- LD50 oral in mouse: > 4gm/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 51454
- Product name
- Methicillin sodium salt
- Purity
- ≥85% (HPLC)
- Packaging
- 50mg
- Price
- $90.5
- Updated
- 2024/03/01
- Product number
- J66414
- Product name
- Methicillin sodium salt, 90+%
- Packaging
- 1g
- Price
- $435
- Updated
- 2024/03/01
- Product number
- J67100
- Product name
- Methicillin sodium salt, 50 mg/ml in distilled water, sterile-filtered
- Packaging
- 5x1ml
- Price
- $821
- Updated
- 2023/06/20
- Product number
- 21007
- Product name
- Methicillin (sodium salt)
- Purity
- ≥90%
- Packaging
- 25mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 21007
- Product name
- Methicillin (sodium salt)
- Purity
- ≥90%
- Packaging
- 50mg
- Price
- $65
- Updated
- 2024/03/01
Methicillin Sodium Salt Chemical Properties,Usage,Production
Description
Methicillin is a semisynthetic penicillin antibiotic that can inhibit bacterial cell wall synthesis. It can be used to study methicillin-resistance in S. aureus.
Uses
Semi-synthetic antibiotic related to Penicillin. Antimicrobial.
Uses
antibacterial
Uses
Targets primarily the cell wall of Gram-positive organisms especially Staphylococcus aureus. Methicillin is used to study bacterium susceptibility, and to inhibit cell-wall synthesis. PBP's are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Methicillin Sodium Salt is inactivated by gastric acid so it is given to cells by other means in which gastric acid is not present in vitro.
Definition
ChEBI: Methicillin sodium is an organic sodium salt. It contains a methicillin(1-).
brand name
Staphcillin (Apothecon).
Clinical Use
During 1960, methicillin sodium, 2,6-dimethoxyphenylpenicillinsodium (Staphcillin), the second penicillin produced asa result of the research that developed synthetic analogs, wasintroduced for medicinal use.
Methicillin sodium is particularly resistant to inactivationby the penicillinase found in staphylococci and somewhatmore resistant than penicillin G to penicillinase fromBacillus cereus.
in vitro
similar to other β-lactam antibiotics, meticillin acts via inhibiting the synthesis of bacterial cell walls. meticillin can block the cross-linkage between the linear peptidoglycan polymer chains by binding to and competitively inhibiting the transpeptidase enzyme or penicillin-binding proteins [1].
in vivo
in a previous animal study, the treatment with methicillin or gentamicin or both was started 3 days after infection to a experimental mouse model of foreign body infection. results found that the treatment showed a significant effect, demonstrated as reduction of bacteria on the foreign body, for all three regimens with a reduction of up to 2 log units, but there was no synergism. however, the actual efficacy of the treatment was poor, though the local methicillin concentrations was greater than the mic for at least 72 h [2].
References
[1] https://en. wikipedia.org/wiki/meticillin
[2] espersen f, frimodt-m ller n, corneliussen l, riber u, rosdahl vt, skinh j p. effect of treatment with methicillin and gentamicin in a new experimental mouse model of foreign body infection. antimicrob agents chemother. 1994 sep;38(9):2047-53.
Methicillin Sodium Salt Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methicillin Sodium Salt manufacturers
- Product
- MethicillinSodium 132-92-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-11
- Product
- Methicillin Sodium Salt 132-92-3
- Price
- US $0.00-0.00/g
- Min. Order
- 100mg
- Purity
- 98%
- Supply Ability
- >1kg
- Release date
- 2021-07-15