carboquone Property

Melting point:

202° (dec)

Boiling point:

460.09°C (rough estimate)

Density 

1.1990 (rough estimate)

refractive index 

1.5600 (estimate)

pka

13.14±0.50(Predicted)

color 

Red to reddish-brown crystals

Safety

Toxicity

LD50 in male mice, male rats (mg/kg): 6.09, 3.88 i.v.; 3.84, 3.16 i.p.; 30.8, 28.0 orally (Masuda, Suzuki)

Hazard and Precautionary Statements (GHS)

carboquone Chemical Properties,Usage,Production

Originator

Esquinon,Sankyo,Japan,1974

Definition

ChEBI: Carboquone is an organic molecular entity.

Manufacturing Process

In 10 ml of ethanol was dissolved with heating 200 mg of 2-methyl-5-(1- methoxy-2-carbamoyloxyethyl)-1,4-benzoquinone and the resulting solution was cooled. To the cooled solution was added 0.5 ml of aziridine and then the resulting mixture was allowed to stand in a refrigerator at 5°C to 8°C for 4 days. Thereafter, the crystalline substance which precipitated in situ was recovered by filtration and washed with ethanol to give 50 mg of the desired product as red crystals melting at 200°C (with decomposition).

Therapeutic Function

Antineoplastic

Safety Profile

A poison via ingestion,intraperitoneal, subcutaneous, and intravenous routes.Mutation data reported. When heated to decomposition itemits toxic NOx.