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Oxaflozane

Product Name
Oxaflozane
CAS No.
26629-87-8
Chemical Name
Oxaflozane
Synonyms
Oxaflozane;4-Isopropyl-2-[3-(trifluoromethyl)phenyl]morpholine;Morpholine, 4-(1-methylethyl)-2-[3-(trifluoromethyl)phenyl]-
CBNumber
CB4875187
Molecular Formula
C14H18F3NO
Formula Weight
273.29
MOL File
26629-87-8.mol
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Oxaflozane Property

Boiling point:
bp0.005 52°; bp3 99°
Density 
1.1358 (estimate)
refractive index 
nD24 1.4751
pka
7.58±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0025181
Product name
OXAFLOZANE
Purity
95.00%
Packaging
5MG
Price
$502.55
Updated
2021/12/16
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Oxaflozane Chemical Properties,Usage,Production

Originator

Conflictan,Sarbach,France,1982

Definition

ChEBI: Oxaflozane is a member of morpholines.

Manufacturing Process

(1) 1,2-Dibromo-2-(2-chloro)ethoxyethane: 640 g of bromine (4 mols) are added dropwise, with stirring, to 426 g (4 mols) of 2-chloroethylvinyl ether dissolved in 1,040 ml of chloroform maintained at -10°C.
When addition is ended, the solvent and then the residue are distilled in vacuum to obtain 690 g of product. Yield = 65%.
(2) 2-(3-Trifluoromethyl)-2-(2-chloro)ethoxy-1-bromoethane: (3Trifluoromethyl)phenyl magnesium bromide is prepared under the normal conditions for magnesium derivatives, from 48.6 g of magnesium turnings and 455.7 g of (3-trifluoromethyl)bromobenzeneand 1.5 liters anhydrous ether.
To the solution of the magnesium compound so obtained the following solution is added dropwise, with stirring so as to maintain a slight reflux of ether: 1,2dibromo-2-(2-chloro)-ethoxyethane: 550 g. Anhydrous ether: 300 ml.
After the addition, reflux heating is continued for two hours, cooling is carried out and there is hydrolysis by the mixture: Ice: 500 g. Concentrated HCl: 200 ml.
The organic phase is decanted, washed in NaCl saturated water and dried on anhydrous Na2SO4; the ether is distilled and the residue is rectified in vacuum to obtain 361 g of the product. Yield = 54%.
According to gas phase chromatography, the product so obtained is about 95% pure and it can be used in further reactions without a second rectification.
(3) 2-(3-Trifluoromethyl)phenyl-4-isopropyl tetrahydro-1,4-oxazine hydrochloride: The following mixture is heated in an autoclave at 100°C; 2-(3trifluoromethyl)-2-(2-chloro)-ethoxy-1-bromoethane: 33.15 g (0.1 mol); isopropylamine: 20 g (0.34 mol); toluene: 100 ml.
After filtration of the isopropylamine hydrochloride and bromohydrate, the solvent is stripped and the residue is admixed with ~ 4 N HCl and the aqueous phase is washed with ether. The aqueous phase is treated with 50% aqueous NaOH, the amine is ether-extracted and, after drying on anhydrous Na2SO4, the ether is distilled and the residue is rectified in vacuum to obtain 14 g of the product. Yield = 50%.
The hydrochloride is crystallized by adding ethyl acetate to the base and then adding the necessary amount of pure alcohol saturated in dry HCl. Melting point 164°C.

Therapeutic Function

Antidepressant

Oxaflozane Preparation Products And Raw materials

Raw materials

Preparation Products

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Oxaflozane Suppliers

Nanjing Finetech Chemical Co., Ltd.
Tel
025-85710122 17714198479
Fax
025-85710122
Email
sales@fine-chemtech.com
Country
CHINA
ProdList
885
Advantage
55

26629-87-8, OxaflozaneRelated Search:


  • Oxaflozane
  • 4-Isopropyl-2-[3-(trifluoromethyl)phenyl]morpholine
  • Morpholine, 4-(1-methylethyl)-2-[3-(trifluoromethyl)phenyl]-
  • 26629-87-8