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tolonidine

Product Name
tolonidine
CAS No.
4201-22-3
Chemical Name
tolonidine
Synonyms
ST-375;tolonidine;N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine;1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
CBNumber
CB4875314
Molecular Formula
C10H12ClN3
Formula Weight
209.68
MOL File
4201-22-3.mol
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tolonidine Property

Melting point:
148-150°
Boiling point:
314.0±52.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
9.41(at 25℃)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
SYN5523
Product name
Tolonidine
Packaging
10mg
Price
$104
Updated
2021/12/16
AK Scientific
Product number
SYN5523
Product name
Tolonidine
Packaging
50mg
Price
$336
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012694
Product name
TOLONIDINE
Purity
95.00%
Packaging
5MG
Price
$495.19
Updated
2021/12/16
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tolonidine Chemical Properties,Usage,Production

Originator

Euctan,Essex,Switz.,1978

Definition

ChEBI: Tolonidine is a substituted aniline.

Manufacturing Process

43 g of the thiourea compound (melting point 124°C) obtained in known fashion from 2-chloro-4-methylaniline and ammonium thiocyanate and 20 cc of methyl iodide were dissolved in 200 cc of methanol, and the solution was refluxed for two hours.1 Thereafter, the solvent was evaporated in vacuo, leaving 73.2 g of the isothiouronium hydroiodide of the formula as a residue. This isothiouronium salt was admixed with 20 cc of ethylenediamine, and the mixture was heated for about 30 minutes at 150°C to 160°C, accompanied by stirring; methyl mercaptan escaped during that time. Subsequently, the reaction mixture was taken up in hot dilute acetic acid, and the resulting solution was made alkaline with 2 N sodium hydroxide. A precipitate formed, which was separated by vacuum filtration, washed with water and dried. It was identified to be 2-(2'-chloro-4'-methylphenyl)-amino-1,3- diazacyclopentene-(2) having a melting point of 142°C to 145°C. The yield was 10.2 g.
The nitrate of the base, obtained by acidifying a solution of the free base with nitric acid, had a melting point of 162°C to 164°C and was soluble in water and methanol.

Therapeutic Function

Antihypertensive

tolonidine Preparation Products And Raw materials

Raw materials

Preparation Products

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tolonidine Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29774
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58

4201-22-3, tolonidineRelated Search:


  • tolonidine
  • N-(2-Chloro-4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine
  • ST-375
  • 1H-Imidazol-2-amine, N-(2-chloro-4-methylphenyl)-4,5-dihydro-
  • 4201-22-3
  • C10H12ClN3