ChemicalBook > CAS DataBase List > 4,4'-(dithiodicarbonothioyl)dimorpholine

4,4'-(dithiodicarbonothioyl)dimorpholine

Product Name: 4,4'-(dithiodicarbonothioyl)dimorpholine
CAS No.: 729-46-4
Chemical Name: 4,4'-(dithiodicarbonothioyl)dimorpholine
Synonyms: JX 06;JX06 ，S0983;JX06, 10 mM in DMSO;Bis(morpholinothiocarbonyl) disulfide;DI(4-MORPHOLINYL)DITHIOPEROXYANHYDRIDE;Bis(morpholinocarbonothioyl) persulfide;4,4'-(dithiodicarbonothioyl)dimorpholine;Morpholine, 4,4-(dithiodicarbonothioyl)bis-;Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK
CBNumber: CB4875824
Molecular Formula: C10H16N2O2S4
Formula Weight: 324.51
MOL File: 729-46-4.mol

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4,4'-(dithiodicarbonothioyl)dimorpholine Property

Melting point:: 136-137 °C
Boiling point:: 466.3±55.0 °C(Predicted)
Density: 1.4302 (rough estimate)
refractive index: 1.5650 (estimate)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
pka: 0.58±0.20(Predicted)
color: White to off-white
EPA Substance Registry System: Morpholine, 4,4'-(dithiodicarbonothioyl)bis- (729-46-4)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P314Get medical advice/attention if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 5845
Product name: JX06
Purity: ≥98%(HPLC)
Packaging: 10
Price: $85
Updated: 2021/12/16

Tocris

Product number: 5845
Product name: JX06
Purity: ≥98%(HPLC)
Packaging: 50
Price: $357
Updated: 2021/12/16

TRC

Product number: J211958
Product name: JX06
Packaging: 2.5mg
Price: $105
Updated: 2021/12/16

ChemScene

Product number: CS-0015656
Product name: JX06
Purity: 99.88%
Packaging: 25mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-0015656
Product name: JX06
Purity: 99.88%
Packaging: 5mg
Price: $50
Updated: 2021/12/16

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4,4'-(dithiodicarbonothioyl)dimorpholine Chemical Properties,Usage,Production

Uses

JX 06 is a covalent inhibitor of Potent Covalent Pyruvate Dehydrogenase Kinase (PDK).

Biological Activity

JX06 is a potent, PDK1-selective, covalent pyruvate dehydrogenase (PDH) kinase (PDHK, PDK) inhibitor (PDK1/2/3 IC50 = 49/101/313 nM; PDK4 IC50 >10 μM, IC50 >10 μM against >300 other kinases). JX06 inhibits cellular PDK substrate PDHA1 Ser293/232 phosphorylation, resulting in reduced aerobic glycolysis and cancer proliferation in cultures (1-10 μM) and in mice in vivo (40-80 mg/kg via daily i.p. injection; A549 & HT-29 xenografts). JX06 is shown to target PDK1 Cys240 for covalent modification.

in vivo

JX06 (40-80?mg/kg; i.p. for 21 days) inhibits tumor growth in vivo^[1].

Animal Model:	A549 subcutaneous xenograft mice^[1]
Dosage:	40, 80?mg/kg
Administration:	I.p. injections for 21 days
Result:	Reduced tumor weights and 67.5% tumor volume at the dose of 80 mg/kg compared with the vehicle control. Well tolerated at the administration dose.

storage

Store at -20°C

4,4'-(dithiodicarbonothioyl)dimorpholine Preparation Products And Raw materials

Raw materials

Preparation Products

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729-46-4, 4,4'-(dithiodicarbonothioyl)dimorpholineRelated Search:

4,4'-(dithiodicarbonothioyl)dimorpholine

Morpholine, 4,4-(dithiodicarbonothioyl)bis-

Bis(morpholinocarbonothioyl) persulfide

JX 06

Bis(morpholinothiocarbonyl) disulfide

Apoptosis,JX06,JX-06,Inhibitor,PDH kinase,inhibit,Pyruvate dehydrogenase kinase,JX 06,PDHK

JX06, 10 mM in DMSO

DI(4-MORPHOLINYL)DITHIOPEROXYANHYDRIDE

JX06 ，S0983

729-46-4

C10H16N2O2S4