ARV-471

ChemicalBook > CAS DataBase List > ARV-471

Product Name: ARV-471
CAS No.: 2229711-68-4
Chemical Name: ARV-471
Synonyms: ARV-471;Vepdegestrant;Vepdegestrant（ARV-471）;3-(4-hydroxy-6-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione;(S)-3-(5-(4-((1-(4-((1R,2S)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione;oral,Inhibitor,breast cancer,PROTAC,E3 ligase,inhibit,hetero-bifunctional,ubiquitylation,ARV-471,PROTACs,Estrogen Receptor/ERR,ARV 471,estrogen receptor,ARV471,proteasome;2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-
CBNumber: CB48816045
Molecular Formula: C45H49N5O4
Formula Weight: 723.9
MOL File: 2229711-68-4.mol

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ARV-471 Property

Density: 1.275±0.06 g/cm3(Predicted)
solubility: DMSO : 110 mg/mL (151.95 mM; Need ultrasonic)
form: Solid
pka: 10.36±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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ARV-471 Chemical Properties,Usage,Production

Uses

ARV-471 is a best-in-class, orally active estrogen receptor (ER) PROTAC degrader. It is developed for the research of breast cancer.

Biological Activity

ARV-471 is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. It leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. ARV-471 robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM.

ARV-471 Preparation Products And Raw materials

Raw materials

Preparation Products

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2229711-68-4, ARV-471Related Search:

2,6-Piperidinedione, 3-[1,3-dihydro-1-oxo-5-[4-[[1-[4-[(1R,2S)-1,2,3,4-tetrahydro-6-hydroxy-2-phenyl-1-naphthalenyl]phenyl]-4-piperidinyl]methyl]-1-piperazinyl]-2H-isoindol-2-yl]-, (3S)-

ARV-471

Vepdegestrant

Vepdegestrant（ARV-471）

(S)-3-(5-(4-((1-(4-((1R,2S)-6-Hydroxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione

oral,Inhibitor,breast cancer,PROTAC,E3 ligase,inhibit,hetero-bifunctional,ubiquitylation,ARV-471,PROTACs,Estrogen Receptor/ERR,ARV 471,estrogen receptor,ARV471,proteasome

3-(4-hydroxy-6-methyl-1-oxoisoindolin-2-yl)piperidine-2,6-dione

2229711-68-4

C45H49N5O4

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