CDK4/6-IN-6

Product Name: CDK4/6-IN-6
CAS No.: 2380321-51-5
Chemical Name: CDK4/6-IN-6
Synonyms: PF-07220060;CDK4/6-IN-6;CDK4-IN-I (PF-07220060);CDK4/6-IN-6, 10 mM in DMSO;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol;1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol
CBNumber: CB48845087
Molecular Formula: C22H27ClFN5O3
Formula Weight: 463.94
MOL File: 2380321-51-5.mol

More

Less

CDK4/6-IN-6 Property

Boiling point:: 687.4±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
form: Solid
pka: 13.43±0.29(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

CDK4/6-IN-6 Chemical Properties,Usage,Production

Biological Activity

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

References

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

CDK4/6-IN-6 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CDK4/6-IN-6 Suppliers

China 51 United States 2 Global 53

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5127
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 14760821013 13564957716
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: 18616377689
Email: nanfengdrug@163.com
Country: China
ProdList: 20010
Advantage: 58

Chengdu PEIP Pharmaceutical Technology Co., LTD.

Tel: 028-61715638 18011352545
Fax: QQ：1242335375
Email: 1242335275@qq.com
Country: China
ProdList: 367
Advantage: 58

Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.

Tel: 13771642864
Fax: 1078336263
Email: snhuyu_2008@126.com
Country: China
ProdList: 1112
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 264
Advantage: 61

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4001
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4569
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

2380321-51-5, CDK4/6-IN-6Related Search:

PF-07220060

1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol

CDK4/6-IN-6

CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6

CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6

(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol

CDK4-IN-I (PF-07220060)

(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol

CDK4/6-IN-6, 10 mM in DMSO

2380321-51-5