CDK4/6-IN-6

Product Name: CDK4/6-IN-6
CAS No.: 2380321-51-5
Chemical Name: CDK4/6-IN-6
Synonyms: PF-07220060;CDK4/6-IN-6;CDK4-IN-I (PF-07220060);PF-07220060 (CDK4/6-IN-6);CDK4/6-IN-6, 10 mM in DMSO;CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6;CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6;(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol;(3S,4R)-4-((5-chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzimidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol;(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol
CBNumber: CB48845087
Molecular Formula: C22H27ClFN5O3
Formula Weight: 463.94
MOL File: 2380321-51-5.mol

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CDK4/6-IN-6 Property

Boiling point:: 687.4±65.0 °C(Predicted)
Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
form: Solid
pka: 13.43±0.29(Predicted)
color: White to off-white
InChIKey: QYJLBHRAPDJOSO-JBKWZTHDNA-N
SMILES: C(N1C(=NC2=C(C=C(C3C(=CN=C(N[C@@H]4CCOC[C@H]4O)N=3)Cl)C=C12)F)C(O)(C)C)(C)C |&1:14,19,r|

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Hazard and Precautionary Statements (GHS)

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CDK4/6-IN-6 Chemical Properties,Usage,Production

Biological Activity

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1]. CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

References

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.

CDK4/6-IN-6 Preparation Products And Raw materials

Raw materials

Preparation Products

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CDK4/6-IN-6 Suppliers

China 59 United States 1 Global 60

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2380321-51-5, CDK4/6-IN-6Related Search:

PF-07220060

1,5-anhydro-3-((5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1 H-benzimidazol-6- yl]pyrimidin-2-yl)amino)-2,3-dideoxy-D-threo-pentitol

CDK4/6-IN-6

CDK4/6-IN-6CDK4/CDK4/6-IN-66-IN-6

CDK-4/6-IN-6,Inhibitor,inhibit,CDK,Cyclin,Cyclin dependent kinase,CDK4/6 IN 6,CDK4/6IN6

(3S,4R)-4-[[5-chloro-4-[7-fluoro-2-(1-hydroxy-1-methyl-ethyl)-3-isopropyl-benzimidazol-5-yl]pyrimidin-2-yl]amino]tetrahydropyran-3-ol

CDK4-IN-I (PF-07220060)

(3S,4R)-4-((5-Chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol

CDK4/6-IN-6, 10 mM in DMSO

PF-07220060 (CDK4/6-IN-6)

(3S,4R)-4-((5-chloro-4-(4-fluoro-2-(2-hydroxypropan-2-yl)-1-isopropyl-1H-benzimidazol-6-yl)pyrimidin-2-yl)amino)tetrahydro-2H-pyran-3-ol

2380321-51-5