Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

Product Name: Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-
CAS No.: 2031152-08-4
Chemical Name: Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-
Synonyms: XMU-MP-3;Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-
CBNumber: CB49009778
Molecular Formula: C27H27F3N8O
Formula Weight: 536.55
MOL File: 2031152-08-4.mol

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Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- Property

Density: 1.38±0.1 g/cm3(Predicted)
pka: 12.78±0.70(Predicted)
form: Solid
color: Light yellow to brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0130091
Product name: XMU-MP-3
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0130091
Product name: XMU-MP-3
Packaging: 10mg
Price: $780
Updated: 2021/12/16

ChemScene

Product number: CS-0130091
Product name: XMU-MP-3
Packaging: 50mg
Price: $2300
Updated: 2021/12/16

ChemScene

Product number: CS-0130091
Product name: XMU-MP-3
Packaging: 100mg
Price: $3600
Updated: 2021/12/16

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Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- Chemical Properties,Usage,Production

Uses

XMU-MP-3 is a potent non-covalent BTK inhibitor with IC50s of 10.7 nM and 17.0 nM for BTK WT and BTK C481S mutation in the presence of 10 μM ATP, respectively. XMU-MP-3 also induces apoptosis[1].

in vivo

XMU-MP-3 (25 and 50 mg/kg) substantially suppresses tumor growth in mouse xenograft models^[1].

Animal Model:	Nu/nu BALB/c mice (4-6 weeks of age) bearing BTK-transformed Ba/F3 and Ramos xenograft models^[1]
Dosage:	25 and 50 mg/kg
Administration:	Treated by tail vein injection; the injection volume was 0.1 mL per 10 g; daily for 14 days
Result:	Significantly reduced the tumor size without affecting animal weights.

References

[1] Fu Gui, et al. A Non-Covalent Inhibitor XMU-MP-3 Overrides Ibrutinib-Resistant Btk C481S Mutation in B-cell Malignancies. Br J Pharmacol. 2019 Dec;176(23):4491-4509. DOI:10.1111/bph.14809

Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)- Suppliers

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2031152-08-4, Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-Related Search:

XMU-MP-2 XMU-MP-1

Benzamide, N-[3-[7-[(1,3-dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methylpyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-

XMU-MP-3

2031152-08-4

C27H27F3N8O