Description Mechanism of action
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tromantadine

Description Mechanism of action
Product Name
tromantadine
CAS No.
53783-83-8
Chemical Name
tromantadine
Synonyms
N-(1-Adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide;Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-yl-
CBNumber
CB4917021
Molecular Formula
C16H28N2O2
Formula Weight
280.41
MOL File
53783-83-8.mol
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tromantadine Property

Boiling point:
434.5±28.0 °C(Predicted)
Density 
1.09±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Oil
pka
14.58±0.20(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0004847
Product name
TROMANTADINE
Purity
95.00%
Packaging
5MG
Price
$498.1
Updated
2021/12/16
CSNpharm
Product number
CSN21875
Product name
Tromantadine
Packaging
1mg
Price
$204
Updated
2021/12/16
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tromantadine Chemical Properties,Usage,Production

Description

Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.

Mechanism of action

Tromantadine inhibits the early and late events in the virus replication cycle.It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions.

Originator

Viru-Merz,Merz,W. Germany,1973

Uses

Tromantadine hydrochloride is used as antiviral agent effective against herpes simplex infections.

Definition

ChEBI: Tromantadine is a secondary carboxamide.

Manufacturing Process

Adamantane is first reacted with chloroacetyl chloride to give chloroacetylaminoadamantane. 2.3 g Na (0.1 g-atom) were dissolved in 75 ml dimethylamino-ethanol. Then the excess alcohol was distilled off completely and the sodium salt developed was dried in a vacuum. After drying, the salt was dissolved in about 200 ml xylene. To thissolution.22.8 g (0.1 mol) chloroacetylaminoadamantane were added, heated for 10 hours under reflux in a 250-ml round-bottomed flask with a reflux cooler, and the sodium chloride developed subsequently filtered off.
Next the xylene was distilled away, the liquid residue dissolved in about 80 ml carbon tetrachloride and the hydrochloride precipitated through introduction of hydrochloric acid gas. The hydrochloride was dissolved in about 100 ml acetone and the solvent subsequently distilled away, whereby excess hydrochloric acid passed over with it. This operation was repeated until no excess acid was present.
A large excess of petroleum ether was added in a 500 ml three-necked flask provided with a stirrer and reflux cooler, to a concentrated acetonic solution of the hydrochloride and stirred for at least 1 hour, whereby the desired substance was deposited in a crystalline form. Finally, the substance was filtered away and dried in a desiccator. 14 g of the substance (15% of theory) were obtained.

Therapeutic Function

Antiviral

tromantadine Preparation Products And Raw materials

Raw materials

Preparation Products

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tromantadine Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Beijing Hechemist Technology CO.,LTD
Tel
18511709189
Email
sales@hechemist.com
Country
China
ProdList
3433
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Shanghai Han-Xiang Chemical Co., Ltd.
Tel
15971444841
Fax
18327183813
Email
amber@biochempartner.com
Country
China
ProdList
3061
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Fax
0551-65418697
Email
sales@tnjchem.com
Country
China
ProdList
34553
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652,+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
Advantage
58

53783-83-8, tromantadineRelated Search:


  • N-(1-Adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide
  • Acetamide, 2-[2-(dimethylamino)ethoxy]-N-tricyclo[3.3.1.13,7]dec-1-yl-
  • 53783-83-8