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Antimycin A4

Product Name
Antimycin A4
CAS No.
27220-59-3
Chemical Name
Antimycin A4
Synonyms
antimycin A4;Antimycin A4 (7CI,9CI);Antimycin A4 DISCONTINUED, offer A697508;8-butyl-3-(3-formamido-2-hydroxybenzamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl butyrate;8-Butyl-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-2,6-dimethyl-4,9-dioxo-1,5-dioxonane-7-yl=butyrate;Butyric acid 8-butyl-3-[(3-formylamino-2-hydroxybenzoyl)amino]-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
CBNumber
CB4919500
Molecular Formula
C25H34N2O9
Formula Weight
506.54546
MOL File
27220-59-3.mol
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Antimycin A4 Property

Boiling point:
595.17°C (rough estimate)
Density 
1.3028 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
-20°C
solubility 
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
form 
A solid
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
36/37/39-45
RIDADR 
3172
HazardClass 
6.1(a)
PackingGroup 
II
Toxicity
LD50 ipr-mus: 7600 mg/kg 85FZAT -,146,67
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21999
Product name
Antimycin A4
Purity
≥98%
Packaging
500μg
Price
$231
Updated
2024/03/01
Cayman Chemical
Product number
21999
Product name
Antimycin A4
Purity
≥98%
Packaging
2.5mg
Price
$1096
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0010163
Product name
ANTIMYCIN A4
Purity
95.00%
Packaging
5MG
Price
$504.44
Updated
2021/12/16
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Antimycin A4 Chemical Properties,Usage,Production

Description

Antimycin A4 is an active component of the antimycin A antibiotic complex that is more polar than antimycin A1 , antimycin A2 , and antimycin A3 . Antimycin A4 inhibits ATP-citrate lyase with a Ki value of 64.8 μM. The antimycin A complex is a mixture of antimycins A1, A2, A3, and A4 that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties. It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial electron transport chain (ETC). Antimycin A prevents the transfer of electrons between the b-cytochromes and ubiquinone at the Q(inner) site of complex III. This results in the stabilization of the ubisemiquinone radical at the Q(outer) site of complex III, leading to increased production of superoxide. Antimycin A is widely used in research to shunt electron flow through the ETC to study the chemical details of oxygen respiration. Additionally, antimycin A has been shown to inhibit Bcl-2 and Bcl-xL proteins, inducing apoptosis.

Chemical Properties

Antimycin (A3C26H36N2O9) and (Antimycin A1) C28H40N2O9 are crystalline solids.

Uses

Antimycin A4 is the most polar of the major components of the antimycin complex, first isolated in 1958 from Streptomyces blastimyceticus and co-produced with antimycin A3. Like all antimycins, antimycin A4 is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A4 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active. Lack of availability of the individual antimycin components has hindered greater understanding of the common and unique molecular targets of the components of the antimycin complex.

Safety Profile

Poison by subcutaneous,intravenous, and intraperitoneal routes. When heated todecomposition it emits toxic fumes of NOx.

Potential Exposure

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

Antimycin A4 Preparation Products And Raw materials

Raw materials

Preparation Products

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Antimycin A4 Suppliers

China 19 India 1 South Korea 1 United Kingdom 1 United States 5 Global 27
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Meng Cheng Technology (Shanghai) Co., LTD
Tel
400-820-6829
Email
sales@mitachieve.com
Country
China
ProdList
8860
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
13774214275
Email
zhouzz@univ-bio.com
Country
China
ProdList
24991
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
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Shanghai Yiyan Biotechnology Co. , Ltd.
Tel
021-69985186 13611928337
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3427709316@qq.com
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China
ProdList
7979
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Shanghai Saikerui Biotechnology Co. , Ltd.
Tel
021-58000709 15900491054
Email
info@scrbio.com
Country
China
ProdList
10329
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Shanghai Yifei Biotechnology Co. , Ltd.
Tel
021-65675885 18964387627
Email
customer_service@efebio.com
Country
China
ProdList
11974
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58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
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Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
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Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6906
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Shanghai Bosheng Biotechnology Co., Ltd.
Tel
--
Fax
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1310057982@qq.com
Country
CHINA
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790
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Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
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Email
info@f-biology.com
Country
CHINA
ProdList
6025
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Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
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Email
info@zzsrm.com
Country
CHINA
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6650
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Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
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3007606172@qq.com
Country
CHINA
ProdList
6002
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58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
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Email
1985563437@qq.com
Country
CHINA
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6158
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Boao Pike
Tel
--
Fax
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Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
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58

27220-59-3, Antimycin A4Related Search:

Gentamicin Acetylspiramycin POLYOXIN B ANTIMYCIN A

  • 8-butyl-3-(3-formamido-2-hydroxybenzamido)-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl butyrate
  • antimycin A4
  • 8-Butyl-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-2,6-dimethyl-4,9-dioxo-1,5-dioxonane-7-yl=butyrate
  • Butyric acid 8-butyl-3-[(3-formylamino-2-hydroxybenzoyl)amino]-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
  • Antimycin A4 DISCONTINUED, offer A697508
  • Antimycin A4 (7CI,9CI)
  • 27220-59-3