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xibornol

Product Name
xibornol
CAS No.
13741-18-9
Chemical Name
xibornol
Synonyms
xibornol;Xybornol;Bactacine;Nanbacine;6-Isobornyl-3,4-xylenol;4,5-dimethyl-2-[(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]phenol;Phenol, 4,5-dimethyl-2-[(1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-, rel-
CBNumber
CB4923798
Molecular Formula
C18H26O
Formula Weight
258.4
MOL File
13741-18-9.mol
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xibornol Property

Melting point:
94-96°
Boiling point:
bp3 165-168°; bp9 185-189°
Density 
d420 1.0240
refractive index 
nD20 1.5382 (Starkov, Glushkova)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0025568
Product name
XIBORNOL
Purity
95.00%
Packaging
5MG
Price
$497.29
Updated
2021/12/16
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xibornol Chemical Properties,Usage,Production

Chemical Properties

Crystalline solid or viscous, yellowish liquid.

Originator

Nanbacine,Fournier,France,1976

Uses

Antibacterial agent, rubber antioxidant.

Definition

ChEBI: A bridged compound that is 3,4-xylenol carrying an additional isobornyl substituent at position 6. A lipophilic antibacterial drug mainly used in spray dosage forms for the local treatment of infection and inflammation of the throat.

Manufacturing Process

100 g of 3,4-xylenol and 150 g of camphene are melted in a two-necked flask equipped with a reflux condenser and a thermometer. 10 g of stannic chloride are added in small quantities; the temperature is kept between 70°C and 80°C for 4 hours. The mass is then allowed to cool and 300 ml of benzene and 300 ml of water are added. The aqueous layer is decanted off, and the supernatant organic layer is washed, first with 1,200 ml of 10% potassium hydroxide and then with water until neutral. The benzene is driven off and the mass is distilled. The fraction which passes between 203°C and 223°C/200 mm Hg is collected and recrystallized in petroleum ether.
100 mg of the recrystallized product is dissolved in 10 ml of hexane.
This solution is then slowly passed through a chromatographic alumina column, 20 cm in length and 16 mm in diameter, containing 20 g of alumina (Prolabo).
The column is then eluted with benzene and 2 ml fractions of the eluent are collected as soon as the product appears in the eluent. The presence of the product is detected by means of the color change in the collected eluent after adding 1 drop of 2% ferric chloride and 2 drops of 5% potassium ferricyanide solution.
18 ml of a first fraction are collected, the next 2 ml of eluent are discarded and then a second fraction of 20 ml is collected. Removal of the solvent from the first fraction by distillation leaves a product having a melting point of between 94°C and 96°C and removal of the solvent from the second fraction leaves a product having a melting point between 86°C and 88°C.
The product remaining from the first fraction is 6-isobornyl-3,4-xylenol while that from the second fraction is its isomer 6-exo-isocamphenyl-3,4-xylenol.

Therapeutic Function

Antibacterial

xibornol Preparation Products And Raw materials

Raw materials

Preparation Products

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xibornol Suppliers

BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
Advantage
58
Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd
Tel
18162595016; 18162595016
Email
3287908757@qq.com
Country
China
ProdList
9122
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
GIHI CHEMICALS CO.,LIMITED
Tel
+8618058761490
Email
info@gihichemicals.com
Country
China
ProdList
49978
Advantage
58

13741-18-9, xibornolRelated Search:


  • 6-Isobornyl-3,4-xylenol
  • Nanbacine
  • Xybornol
  • xibornol
  • Phenol, 4,5-dimethyl-2-[(1R,2S,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]-, rel-
  • Bactacine
  • 4,5-dimethyl-2-[(1R,3R,4S)-4,7,7-trimethyl-3-bicyclo[2.2.1]heptanyl]phenol
  • 13741-18-9