diethyl 1,1-cyclopentanedicarboxylate
- Product Name
- diethyl 1,1-cyclopentanedicarboxylate
- CAS No.
- 4167-77-5
- Chemical Name
- diethyl 1,1-cyclopentanedicarboxylate
- Synonyms
- Ai3-11605;NSC 67352;Einecs 224-024-8;1,1-Bis(ethoxycarbonyl)cyclopentane;diethyl 1,1-cyclopentanedicarboxylate;Diethyl cyclopentane-1,1-dicarboxylate;Cyclopentane-4,4-dicarboxylic acid diethyl ester;1,1-Cyclopentanedicarboxylic acid, diethyl ester;1,1-Cyclopentanedicarboxylic acid 1,1-diethyl ester
- CBNumber
- CB4924816
- Molecular Formula
- C11H18O4
- Formula Weight
- 214.26
- MOL File
- 4167-77-5.mol
diethyl 1,1-cyclopentanedicarboxylate Property
- Boiling point:
- 246℃
- Density
- 1.096
- refractive index
- 1.4450
- Flash point:
- 110℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 29172090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- VBP00094
- Product name
- Diethyl cyclopentane-1,1-dicarboxylate
- Purity
- Aldrich<SUP>CPR</SUP>
- Packaging
- 1 g
- Price
- $58.6
- Updated
- 2025/07/31
- Product number
- D442263
- Product name
- DiethylCyclopentane-1,1-dicarboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 099463
- Product name
- Diethyl cyclopentane-1,1-dicarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $975
- Updated
- 2021/12/16
- Product number
- 5741AB
- Product name
- Diethylcyclopentane-1,1-dicarboxylate
- Packaging
- 5g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- 099463
- Product name
- Diethyl cyclopentane-1,1-dicarboxylate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $435
- Updated
- 2021/12/16
diethyl 1,1-cyclopentanedicarboxylate Chemical Properties,Usage,Production
Synthesis
110-52-1
105-53-3
4167-77-5
1. 1,4-dibromobutane and diethyl malonate are dissolved in DMF under nitrogen protection. 2. Potassium carbonate (K2CO3) and tetrabutylammonium fluoride (TBAF) were added sequentially to the above solution. 3. The reaction mixture was stirred at room temperature overnight. 4. 4. Upon completion of the reaction, the reaction was quenched with 200 mL of cold water. 5. The reaction mixture was extracted with a 10% ethyl acetate/hexane solvent mixture (3 x 150 mL). 6. The organic layers were combined and washed sequentially with half-saturated brine (150 mL x 2) and brine (150 mL). 7. The organic layer was dried with anhydrous sodium sulfate (Na2SO4), filtered and concentrated to dryness. 8. The residue was purified by fast silica gel column chromatography using 2% ethyl acetate/hexane as eluent to give 36.7 g (84% yield) of ethyl 1,1-dicarboxylate cyclopentane as a colorless oil.
References
[1] Tetrahedron Letters, 2005, vol. 46, # 4, p. 635 - 638
[2] Patent: WO2013/185202, 2013, A1. Location in patent: Paragraph 00280; 00281
[3] Patent: WO2015/95227, 2015, A2. Location in patent: Page/Page column 96; 97
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 989 - 1000
[5] Journal of the American Chemical Society, 2010, vol. 132, # 41, p. 14409 - 14411
diethyl 1,1-cyclopentanedicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from diethyl 1,1-cyclopentanedicarboxylate manufacturers
- Product
- Diethyl cyclopentane-1,1-dicarboxylate 4167-77-5
- Price
- US $1.00-15.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 210000KG
- Release date
- 2024-07-23
- Product
- 2,2,3-Trimethylbut-3-enoic acid 4167-77-5
- Price
- US $1.00-15.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 210000KG
- Release date
- 2024-07-23
- Product
- diethyl cyclopentane-1,1-dicarboxylate 4167-77-5
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95--99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09