tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate

Product Name: tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate
CAS No.: 54503-10-5
Chemical Name: tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate
Synonyms: Boc-DL-prolinaMide;N-Boc-D-Prolinamide;L-1-BOC-PROLINAMIDE;N-Boc-DL-prolinamide;1-Boc-piperidine-2-carboxamide;1-Boc-2-(AMinocarbonyl)pyrrolidine;1-(tert-Butoxycarbonyl)piperidine-2-carboxamide;tert-butyl 2-carbaMoylpyrrolidine-1-carboxylate;tert-Butyl 2-carbamoyllpyrrolidine-1-carboxylate;ert-butyl2-(aminocarbonyl)pyrrolidine-1-carboxylate
CBNumber: CB4935285
Molecular Formula: C10H18N2O3
Formula Weight: 214.26
MOL File: 54503-10-5.mol

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tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Property

Boiling point:: 370.1±31.0 °C(Predicted)
Density: 1.155±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 15.97±0.20(Predicted)
Appearance: White to off-white Solid
optical activity: Consistent with structure

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B129700
Product name: tert-Butyl2-Carbamoylpyrrolidine-1-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150612
Product name: DL-1-Boc-prolinamide
Packaging: 100mg
Price: $73
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150612
Product name: DL-1-Boc-prolinamide
Packaging: 250mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150612
Product name: DL-1-Boc-prolinamide
Packaging: 500mg
Price: $255
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB150612
Product name: DL-1-Boc-prolinamide
Packaging: 1g
Price: $440
Updated: 2021/12/16

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tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

15761-39-4

54503-10-5

GENERAL METHOD: 20 g (93 mmol) of Boc-L-proline was dissolved in 150 mL of anhydrous acetonitrile, and 19.5 g (120 mmol) of 1,1'-carbonyldiimidazole, 21.0 mL (150 mmol) of trimethylamine, and 19.2 g (200 mmol) of ammonium carbonate were added sequentially. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was poured into 250 mL of saturated potassium carbonate solution and extracted with dichloromethane (3 x 250 mL). The organic phases were combined, washed twice with 150 mL of water and dried over sodium sulfate. After removing the solvent under reduced pressure, the crude product was purified by rapid chromatography on silica gel with the eluent being ethylhexane-ethyl acetate (100:0→1:1). The product was obtained as 12.3 g in 62% yield. MS data: m/z (Irel, %) 215.1 (100) [M + H]+.

References

[1] Russian Journal of General Chemistry, 2017, vol. 87, # 4, p. 717 - 730
[2] Zh. Obshch. Khim., 2017, vol. 87, # 4, p. 584 - 596,13
[3] Synthetic Communications, 2007, vol. 37, # 21, p. 3793 - 3799
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 9, p. 2225 - 2239
[5] Tetrahedron, 2008, vol. 64, # 12, p. 2801 - 2815

tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylate Suppliers

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54503-10-5, tert-butyl 2-(aminocarbonyl)pyrrolidine-1-carboxylateRelated Search:

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54503-10-5