4'-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone hydrochloride
- Product Name
- 4'-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone hydrochloride
- CAS No.
- 31848-02-9
- Chemical Name
- 4'-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone hydrochloride
- Synonyms
- Morclofone hydrochloride;4'-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone hydrochloride
- CBNumber
- CB4938327
- Molecular Formula
- C21H25Cl2NO5
- Formula Weight
- 442.3329
- MOL File
- 31848-02-9.mol
N-Bromosuccinimide Price
- Product number
- HCH0297477
- Product name
- 4'-CHLORO-3,5-DIMETHOXY-4-(2-MORPHOLINOETHOXY)BENZOPHENONE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.5
- Updated
- 2021/12/16
4'-chloro-3,5-dimethoxy-4-(2-morpholinoethoxy)benzophenone hydrochloride Chemical Properties,Usage,Production
Originator
Plausitin,Carlo Erba,Italy,1975
Manufacturing Process
Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with 3,5-dimethoxy-4'-chloro-4-hydroxybenzophenone (6 g) in dimethylformamide (50 ml), for 2 hours at 120°C. The reaction mixture was then treated with β- morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140C, then evaporated to dryness, and treated with water to give a solid material. The mixture was filtered, washed and crystallized from cyclohexane to give 3,5- dimethoxy-4'-chloro-4-(β-morpholinoethoxy)-benzophenone (6.5 g), MP 91°C to 92°C. The product was then reacted at about 0°C with gaseous hydrogen chloride in ether to give, after crystallization from isopropanol, the corresponding hydrochloride which had a MP of 187.9°C.
Therapeutic Function
Antitussive