(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
- Product Name
- (±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
- CAS No.
- 60398-91-6
- Chemical Name
- (±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
- Synonyms
- Einecs 262-216-3;KJBONRGCLLBWCJ-UHFFFAOYSA-O;Bufuralol hydrochloride (Ro 3-4787);α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride;(1)-alpha-(((tert-Butyl)amino)methyl)-7-ethyl-2-benzofuranmethanolhydr ochloride
- CBNumber
- CB4939096
- Molecular Formula
- C16H24ClNO2
- Formula Weight
- 297.82026
- MOL File
- 60398-91-6.mol
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Property
- Melting point:
- 143-146 °C
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- solid
- color
- white to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- UC168
- Product name
- (±)-Bufuralol hydrochloride
- Packaging
- 5mg
- Price
- $1440
- Updated
- 2024/03/01
- Product number
- UC168
- Product name
- (±)-Bufuralol hydrochloride
- Packaging
- 10mg
- Price
- $2550
- Updated
- 2024/03/01
- Product number
- 17794
- Product name
- Bufuralol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 17794
- Product name
- Bufuralol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 17794
- Product name
- Bufuralol (hydrochloride)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $505
- Updated
- 2024/03/01
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride Chemical Properties,Usage,Production
Description
Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. Bufuralol hydrochloride is a CYP2D6 probe substrate.
Uses
A β-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.
Uses
CYP2D6 substrate
Biochem/physiol Actions
Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
in vitro
Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.
in vivo
Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers.
References
[1] fothergill ga, francis rj, hamilton tc, osbond jm, parkes mw. bufuralol, a new beta-adrenoceptor blocking agent. experientia. 1975 nov 15;31(11):1322-3.
[2] pringle, t. h.,francis, r.j.,east, p.b., et al. pharmacodynamic and pharmacokinetic studies on bufuralol in man. br.j.clin.pharmac. 22, 527-534 (1986).