3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

Product Name: 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
CAS No.: 35773-42-3
Chemical Name: 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone
Synonyms: ChemBridge-5213777;EMI1 (EGFR MaMTH Inhibitor 1);3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone;3-(Benzoxazol-2-yl)-7-diethylamino-2H-1-benzopyran-2-one;3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one;3-(Benzo[d]oxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one;2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-;7-(Diethylamino)-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one;3-(Benzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one
CBNumber: CB4942287
Molecular Formula: C20H18N2O3
Formula Weight: 334.37
MOL File: 35773-42-3.mol

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3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Property

Melting point:: 185-186 °C(Solv: N,N-dimethylformamide (68-12-2))
Boiling point:: 551.0±60.0 °C(Predicted)
Density: 1.284±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 2mg/mL, clear
form: Solid
pka: 2.94±0.20(Predicted)
color: Light yellow to yellow
EPA Substance Registry System: 2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)- (35773-42-3)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2914
Product name: EMI1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $62.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2914
Product name: EMI1
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: CHM0303817
Product name: 3-(BENZOXAZOL-2-YL)-7-(DIETHYLAMINO)-2-BENZOPYRONE
Purity: 95.00%
Packaging: 5MG
Price: $500.21
Updated: 2021/12/16

DC Chemicals

Product number: 012112
Product name: EMI1(EGFRMaMTHInhibitor1)
Packaging: 001
Price: $950
Updated: 2021/12/16

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3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Chemical Properties,Usage,Production

Uses

EMI1 is an EGFR ex19del/T790M/C797S and EGFR L858R/T790M/C797S inhibitor. EMI1 can be used for the research of mutant EGFR-associated, drug-resistant non-small-cell lung cancer (NSCLC)[1].

Biological Activity

EMI1 (ChemBridge 5213777) is a call penetrant and potent inhibitor of EGFR signaling in EGFR L858R/T790M/C797S and ex19del/T790M/C797S triple mutants associated with drug-resistant NSCLC. Additionally, EMI1 potently depolymerized interphase microtubules, disrupts spindle formation and induced mitotic block in PC9 EGFR ex19del/T790M/C797S cells. EMI1 exhibits potent anti-proliferative activity against various cancer cell lines.

IC 50

EGFR^{del19 T790M C797S}; EGFR^{L858R/T790M/C797S}

References

[1] Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586. DOI:10.1038/s41589-020-0484-2

3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Suppliers

China 20 Finland 2 Russia 1 South Korea 1 United States 2 Global 26

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35773-42-3, 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone Related Search:

Disperse Yellow 232 (E)-2-Styrylbenzoxazole 7-(diethylamino)-3-(5-methylbenzoxazol-2-yl)-2-benzopyrone 2-ETHYL-BENZOOXAZOLE BENZOOXAZOL-2-YL-ACETIC ACID 3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

2H-1-Benzopyran-2-one, 3-(2-benzoxazolyl)-7-(diethylamino)-

3-(Benzoxazol-2-yl)-7-diethylamino-2H-1-benzopyran-2-one

3-(Benzoxazole-2-yl)-7-(diethylamino)-2H-1-benzopyran-2-one

7-(Diethylamino)-3-(benzoxazole-2-yl)-2H-1-benzopyran-2-one

3-(1,3-benzoxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

3-(benzoxazol-2-yl)-7-(diethylamino)-2-benzopyrone

EMI1 (EGFR MaMTH Inhibitor 1)

3-(Benzo[d]oxazol-2-yl)-7-(diethylamino)-2H-chromen-2-one

ChemBridge-5213777

35773-42-3