5-Bromoacetyl-2-hydroxybenzaldehyde
- Product Name
- 5-Bromoacetyl-2-hydroxybenzaldehyde
- CAS No.
- 115787-50-3
- Chemical Name
- 5-Bromoacetyl-2-hydroxybenzaldehyde
- Synonyms
- Salbutamol Impurity 29;Salbutamol Impurity 18;Salbutamol Impurity 134;Levalbuterol Impurity 13;Salbutamol EP Impurity 20;5-(Bromoacetyl)salicylaldehyde;5-bromoacetyl-3-hydroxybenzaldehyde;5-Bromoacetyl-2-hydroxybenzaldehyde;Benzaldehyde,5-(2-broMoacetyl)-2-hydroxy-;5-Bromoacetyl-2-hydroxybenzaldehyde ISO 9001：2015 REACH
- CBNumber
- CB4946876
- Molecular Formula
- C9H7BrO3
- Formula Weight
- 243.05
- MOL File
- 115787-50-3.mol
5-Bromoacetyl-2-hydroxybenzaldehyde Property
- Melting point:
- 117-118 °C(Solv: dichloromethane (75-09-2))
- Boiling point:
- 368.3±32.0 °C(Predicted)
- Density
- 1.685±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 5.93±0.20(Predicted)
- color
- Yellow to Dark Yellow
- Stability:
- Moisture Sensitive
- InChI
- InChI=1S/C9H7BrO3/c10-4-9(13)6-1-2-8(12)7(3-6)5-11/h1-3,5,12H,4H2
- InChIKey
- LPSGRBXPXIPMPF-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(C(CBr)=O)=CC=C1O
N-Bromosuccinimide Price
- Product number
- B679340
- Product name
- 5-(Bromoacetyl)salicylaldehyde
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB151380
- Product name
- 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde
- Packaging
- 2mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- FB151380
- Product name
- 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde
- Packaging
- 5mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- FB151380
- Product name
- 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde
- Packaging
- 10mg
- Price
- $203
- Updated
- 2021/12/16
- Product number
- FB151380
- Product name
- 5-(2-Bromo-acetyl)-2-hydroxy-benzaldehyde
- Packaging
- 25mg
- Price
- $405
- Updated
- 2021/12/16
5-Bromoacetyl-2-hydroxybenzaldehyde Chemical Properties,Usage,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the preparation of Salmeterol (S090100).
Synthesis
90-02-8
598-21-0
115787-50-3
To a suspension of aluminum chloride (4 mole equivalents) in dichloromethane (10 volumes), bromoacetyl bromide (1.2 mole equivalents) was added slowly and dropwise at 100 °C, and the temperature of the reaction system was subsequently adjusted to 30 °C. The reaction mixture was stirred continuously for 1 hour, and then 2-hydroxybenzaldehyde (1 mole equivalent) was added dropwise in dichloromethane. The reaction mixture was stirred continuously at this temperature for 1 h. Then a dichloromethane solution of 2-hydroxybenzaldehyde (1 mole equivalent) was added dropwise. The reaction mixture was stirred at 35-40 °C for 12-15 hours, followed by quenching the reaction with water at 0-50 °C. The organic layer (dichloromethane layer) was separated and the solvent was removed by distillation. To the residue n-heptane was added and stirred for 15 minutes. The resulting slurry was filtered and the wet filter cake was washed with n-heptane (2 vol). The wet filter cake was dried to constant weight at 50 °C to give the intermediate 5-bromoacetyl-2-hydroxybenzaldehyde (2a). Yield: 55% (w/w); HPLC purity: 97-99
References
[1] Angewandte Chemie - International Edition, 2016, vol. 55, # 13, p. 4194 - 4198
[2] Angew. Chem., 2016, vol. 128, # 13, p. 4266 - 4270,5
[3] Tetrahedron Asymmetry, 2008, vol. 19, # 15, p. 1824 - 1828
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1548 - 1552
[5] Chemical Communications, 2018, vol. 54, # 25, p. 3106 - 3109
5-Bromoacetyl-2-hydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromoacetyl-2-hydroxybenzaldehyde manufacturers
- Product
- 5-Bromoacetyl-2-hydroxybenzaldehyde 115787-50-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-31
- Product
- 5-Bromoacetyl-2-hydroxybenzaldehyde 115787-50-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 5-Bromoacetyl-2-hydroxybenzaldehyde 115787-50-3
- Price
- US $1000.00/ASSAYS
- Min. Order
- 100g
- Purity
- 98% Min
- Supply Ability
- 1MT
- Release date
- 2021-01-12