1-(3-Chloropropyl)piperidine HCl

Product Name: 1-(3-Chloropropyl)piperidine HCl
CAS No.: 1458-63-5
Chemical Name: 1-(3-Chloropropyl)piperidine HCl
Synonyms: 3-piperidinopropyl chloride;Piperidine, 1-(3-chloropropyl)-;3-(1-piperidinyl)propyl chloride;1-(3-Chloropropyl)piperidine HCl
CBNumber: CB4946942
Molecular Formula: C8H16ClN
Formula Weight: 161.67
MOL File: 1458-63-5.mol

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1-(3-Chloropropyl)piperidine HCl Property

Boiling point:: 95-103 °C(Press: 25 Torr)
Density: 0.9951 g/cm3
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 9.15±0.10(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C371340
Product name: 1-(3-Chloropropyl)piperidine
Packaging: 5g
Price: $580
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC156648
Product name: 1-(3-Chloropropyl)piperidine HCl
Packaging: 10g
Price: $650
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-27
Product name: 1-(3-Chloropropyl)piperidine
Packaging: 1g
Price: $752
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC156648
Product name: 1-(3-Chloropropyl)piperidine HCl
Packaging: 500g
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR950692
Product name: 1-(3-Chloropropyl)piperidine
Purity: 95%
Packaging: 250mg
Price: $185
Updated: 2021/12/16

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1-(3-Chloropropyl)piperidine HCl Chemical Properties,Usage,Production

Chemical Properties

Boiling point 90℃/2kPa, hydrochloride is crystalline, melting point 218-220℃.

Uses

1-(3-Chloropropyl)piperidine was used as a reactant in the preparation of non-imidazole heterocyclic histamine H3 receptor antagonists.

Synthesis

110-89-4

109-70-6

1458-63-5

General procedure: 160 g (1.016 mol) of 1-bromo-3-chloropropane was added to the reactor at a temperature of 20±5°C with constant stirring. 86.1 g (1.011 mol) of piperidine was slowly added dropwise over a period of 2-3 hours. After completion of the dropwise addition, the reaction was continued with stirring for 1 hour. Subsequently, 100 mL of 30% sodium hydroxide solution was added and the reaction was continued for 4 hours. Upon completion of the reaction, a liquid-liquid separation was carried out and the organic phase was dried over anhydrous sodium sulfate. Finally, 127 g of 1-(3-chloropropyl)piperidine was obtained in 78.56% yield.

References

[1] Patent: CN104447620, 2016, B. Location in patent: Paragraph 0053-0055
[2] Patent: CN106749101, 2017, A. Location in patent: Paragraph 0037; 0038
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 8, p. 2394 - 2399
[4] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 19, p. 4666 - 4670
[5] Pharmazie, 1980, vol. 35, # 2, p. 69 - 72

1-(3-Chloropropyl)piperidine HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-Chloropropyl)piperidine HCl Suppliers

China 12 United Kingdom 2 United States 4 Global 18

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1458-63-5, 1-(3-Chloropropyl)piperidine HCl Related Search:

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1-(3-Chloropropyl)piperidine HCl

3-(1-piperidinyl)propyl chloride

3-piperidinopropyl chloride

Piperidine, 1-(3-chloropropyl)-

1458-63-5